Pyrazole derivatives and herbicides containing them

ABSTRACT

A pyrazole derivative of the formula I ##STR1## wherein A is C 1  -C 4  alkyl, C 2  -C 4  alkenyl or C 2  -C 4  alkynyl; B is hydrogen, C 1  -C 3  alkyl, halogen, C 1  -C 3  haloalkyl, C 1  -C 3  alkoxy, C 1  -C 3  alkylthio, C 2  -C 4  alkoxyalkyl, C 2  -C 4  alkylthioalkyl or C 2  -C 4  alkoxycarbonyl; X is C 1  -C 6  alkyl, C 1  -C 6  alkoxy, halogen, nitro, cyano, etc.; Y is --OR 1  (wherein R 1  is C 3  -C 8  cycloalkyl, etc), --O--L--O--R 1  (wherein L is C 1  -C 6  alkylene which may be substituted by C 1  -C 3  alkyl), --O--L--OH, --O--L--O--L--O--R 2  (wherein R 2  is hydrogen, C 1  -C 6  alkyl group, etc.), --O--L--R 3  (wherein R 3  is phenyl which may be substituted by C 1  -C 3   alkyl, etc.), --O--M (wherein M is a 3- to 6-membered alicyclic group), --O--L--M, --O--L--NR 4  R 5  (wherein each of R 4  and R 5  is hydrogen or C 1  -C 6  alkyl, or R 4  and R 5  form a ring together with the adjacent nitrogen atom), --O--L--COOR 4 , --O--CH═CH--COOR 4 , --O--L--CN, --O--L--C(O)--R 2 , --O--L--S(O) n  --R 4  (wherein n is an integer of from 0 to 2), --O--COOR 4 , --O--CONR 4  R 5 , --OP(O)(OR 4 ) 2 , --S(O) n  R 1 , or --S(O) n  --L--O--R 1  ; Z is halogen, nitro, C 1  -C 3  alkoxy, etc.; V is hydrogen, halogen, C 1  -C 4  alkyl or C 1  -C 4  alkoxy; W is hydrogen, halogen, C 1  -C 4  alkyl, etc.; Q is hydrogen, C 1  -C 6  alkyl which may be substituted by halogen, . . . --C(O)--R 7  (wherein R 7  is phenyl which may be substituted), --S(O) 2  R 7 , --P(O)(OR 7 ) 2 , --L--C(O)--R 7 , --L--C(O)--N(R 8 )(R 9 ) (wherein each of R 8  and R 9  is hydrogenor C 1  -C 6  alkyl), --L--R 10  (wherein R 10  is phenyl group may be substituted, C 1  -C 6  alkyl, C 1  -C 7  alkoxy, or hydroxyl), --L--N(R 8 )(R 9 ), --L--OR 11  (wherein R 11  is hydrogen, C 1  -C 6  alkyl, or C 1  -C 6  alkenyl), --L--OC(O)R 12  (wherein R 12  is C 1  -C 6  alkyl or C 1  -C 6  alkoxy), --L--S(O) n  R 11 , --L--SC(O)R 8 , ##STR2## (wherein each of L1 and L2 is methylene, oxygen or sulfur, R 12  is hydrogen or C 1  -C 3  alkyl, and m is 2 or 3); and a salt thereof.

The present invention relates to novel 4-benzoylpyrazole derivatives and selective herbicides containing such derivatives as active ingredients, which are useful particularly as upland field herbicides.

Various herbicides have been developed for practical use from extensive research and development of herbicides for many years, and such herbicides have contributed to a reduction of the labor force required for controlling weeds or to improvement of the productivity of agricultural or horticultural plants.

Even now, it is still desired to develop a new herbicide having superior herbicidal properties. In particular, it is desired to develp an agricultural or horticultural herbicide which is capable of selectively controlling weeds without adversely affecting the crop plant and at a low dose. However, conventional herbicides do not necessarily provide such desired herbicidal properties.

On the other hand, certain compounds of 4-benzoylpyrazole derivatives are known to have herbicidal activities. For example, pyrazolate (common name) and pyrazoxyfen (common name) are practically used as herbicides for paddy fields. While exhibiting excellent herbicidal activities as paddy field herbicides, these compounds are not suitable as upland herbicides since their herbicidal activities are weak against weeds of upland fields. Among 4-benzoylpyrazole derivatives, it is desired to develop a superior compound useful as an upland field herbicide.

The present invention provides a pyrazole derivative having the formula: ##STR3## wherein

A is a C₁ -C₄ alkyl group, a C₂ -C₄ alkenyl group or a C₂ -C₄ alkynyl group;

B is a hydrogen atom, a C₁ -C₃ alkyl group, a halogen atom, a C₁ -C₃ haloalkyl group, a C₁ -C₃ alkoxy group, a C₁ -C₃ alkylthio group, a C₂ -C₄ alkoxyalkyl group, a C₂ -C₄ alkylthioaalkyl group or a C₂ -C₄ alkoxycarbonyl group;

X is a C₁ -C₆ alkyl group, a C₁ -C₆ alkoxy group, a halogen atom, a nitro group, a cyano group, a C₁ -C₆ haloalkyl group, a C₂ -C₆ alkoxyalkyl group, a C₂ -C₆ alkylcarbonyl group, a C₂ -C₆ alkoxycarbonyl group, an aminocarbonyl group substituted independently by hydrogen or by a C₁ -C₆ alkyl group, a C₁ -C₆ haloalkoxy group, a C₁ -C₆ alkylthio group or a C₂ -C₆ alkylthioalkyl group;

Y is --OR¹ (Wherein R¹ is a C₃ -C₈ cycloalkyl group, a C₄ -C₈ cycloalkylalkyl group, a C₃ -C₆ alkenyl group, a C₂ -C₆ alkynyl group, a C₁ -C₆ haloalkyl group, a C₃ C₈ halocycloalkylalkyl group, a C₃ -C₆ haloalkenyl group, a C₂ -C₆ haloalkynyl group, a C₂ -C₆ nitroalkyl group or a phenyl group which may be substituted by a C_(1-C) ₃ alkyl group, a halogen atom, a nitro group or a C₁ -C₃ alkoxy group), --O--L--O--R¹ (Wherein L is a C₁ -C₆ alkylene group which may be substituted by a C₁ -C₃ alkyl group, and R₁ is as defined above), --O--L--OH (wherein L is as defined above), --O--L--O--L--O--R² (wherein L is as defined above, and R² is a hydrogen atom, a C₁ -C₆ alkyl group or a phenyl group which may be substituted by a C₁ -C₃ alkyl group, a halogen atom, a nitro group or a C₁ -C₃ alkoxy group), --O--L--R³ (wherein L is as defined above, and R³ is a phenyl group which may be substituted by a C₁ -C₃ alkyl group, a halogen atom, a nitro group or a C₁ -C₃ alkoxy group), --O--M (wherein M is a 3- to 6-membered alicyclic group containing not more than two sulfur or oxygen atoms and formed by a linkage of from 1 to 4 carbon atoms), --O--L--M (wherein L and M are as defined above), --O--L--NR⁴ R⁵ (wherein L is as defined above and each of R⁴ and R⁵ which may be the same or different is a hydrogen atom or a C₁ -C₆ alkyl group, or R⁴ and R⁵ form a ring together with the adjacent nitrogen atom), --O--L-COOR⁴ (wherein L and R⁴ are as defined above), --O--CH═CH--COOR⁴ (wherein R⁴ is as defined above), --O--L--CN (wherein L is as defined above), --O--L--C(O)--R² (wherein L and R² are as defined above), --O--L--S(O)_(n) --R⁴ (wherein L and R⁴ are as defined above, and n is an integer of from 0 to 2), --O--COOR⁴ (wherein R⁴ are as defined above), --O--CONR⁴ R⁵ (wherein R⁴ and R⁵ are as defined above), --OP(O)(OR⁴)₂ (wherein R⁴ is as defined above), --S(O)_(n) R¹ (wherein R¹ and n are as defined above), or --S(O)_(n) --L--O--R¹ (wherein L, R¹ and n are as defined above);

Z is a halogen atom, a nitro group, a C₁ -C₃ alkoxy group, a trifluoromethyl group, a trifluoromethoxy group, a cyano group or --S(O)_(n) R⁶ (wherein n is as defined above, and R⁶ is a C₁ -C₃ alkyl group or a C₁ -C₃ haloalkyl group);

V is a hydrogen atom, a halogen atom, a C₁ -C₄ alkyl group or a C₁ -C₄ alkoxy group;

W is a hydrogen atom, a halogen atom, a C₁ -C₄ alkyl group, a C₁ -C₄ haloalkyl group, a C₁ -C₄ alkoxy group, a C₂ -C₆ alkoxyalkyl group, a C₂ -C₅ alkoxycarbonyl group, a C₁ -C₃ haloalkoxy group, a nitro group, a cyano group or --S(O)_(n) --R⁶ (wherein n and R⁶ are as defined above); and

Q is a hydrogen atom, a C₁ --C₆ alkyl group which may be substituted by a halogen atom, a C₁ -C₆ alkenyl group which may be substituted by a halogen atom, a C₁ -C₆ alkynyl group which may be substituted by a halogen atom, a cyanomethyl group, --C(O)--R⁷ (wherein R⁷ is a phenyl group which may be substituted by the same or different substituents selected from the group consisting of a C₁ -C₆ alkyl group, a C₁ -C₆ alkenyl group, a C₁ -C₆ alkynyl group, a C₁ -C₆ haloalkyl group, a C₁ -C₆ haloalkenyl group, a C₁ -C₆ haloalkynyl group, a halogen atom, a nitro group and a trifluoromethyl group, a C₁ -C₆ alkyl group, a C₁ -C₆ alkoxy group, or a hydroxyl group), --S(O)₂ R⁷ (wherein R⁷ is as defined above), --P(O)(OR⁷)₂ (wherein R⁷ is as defined above), --L--C(O)--R⁷ (wherein L and R⁷ are as defined above), --L--C(O)--N(R⁸)(R⁹) (wherein L is as defined above, and each of R⁸ and R⁹ which may be the same or different is a hydrogen atom or a C₁ -C₆ alkyl group), --L--R¹⁰ (wherein L is as defined above, and R¹⁰ is a phenyl group which may be substituted by the sam or different substituents selected from the group consisting of a halogen atom, a nitro group and a trifluoromethyl group, a C₁ -C₆ alkyl group, a C₁ -C₆ alkoxy group, or a hydroxyl group), --L--N(R⁸)(R⁹) (wherein L, R⁸ and R⁹ are as defined above), --L--OR¹¹ (wherein L is as defined above, and R¹¹ is a hydrogen atom, a C₁ -C₆ alkyl group, or a C₁ -C₆ alkenyl group), --L--OC(O)R¹² (wherein L is as defined above, and R¹² is a C₁ -C₆ alkyl group or a C₁ C₆ alkoxy group), --L--S(O)_(n) R¹¹ (wherein L, n and R¹¹ are as defined above), --L--SC(O)R⁸ (wherein L and R⁸ are as defined above), ##STR4## (wherein each of L1 and L2 which may be the same or different is a methylene group, an oxygen atom or a sulfur atom, R¹² is a hydrogen atom or a C₁ -C₃ alkyl group, and m is 2 or 3); and a salt thereof.

The present invention also provides a selective herbicidal composition comprising a herbicidally effective amount of at least one pyrazole derivative of the formula I as defined above or its salt and an agricultural carrier or diluent.

Further, the present invention provides a method for selectively controlling weeds, which comprises applying the pyrazole derivative of the formula I as defined above or its salt to the locus to be protected.

Furthermore, the present invention provides a substituted benzene derivative of the formula: ##STR5## wherein G is a carboxyl group, a halocarbonyl group or a cyanocarbonyl group, and X, Y, Z, V and W are as defined above.

Now, the present invention will be described in detail with reference to the preferred embodiments.

In the compound of the formula I of the present inveniton, A, B, X, Y, Z and Q are preferably selected from the following substituents, respectively:

A:Me, Et, n-Pr, i-Pr, CH₂ CH═CH₂, CH₂ C.tbd.CH, t-Bu

B:H, Me, Et, n-Pr, i-Pr, Cl, Br, CH₂ Cl, CF₃, OMe, OEt, OPr-i, SMe, CH₂ OMe, CH₂ SMe, CO₂ Me, CO₂ Et

X:Me, Et, n-Pr, i-Pr, n-Bu, i-Bu, s-Bu, t-Bu, OMe, OEt, OPr-n, OPr-n, OPr-i, OBu-n, OBu-i, OBU-s, OBu-t, F, Cl, Br, I, NO₂ CN, CH₂ F, CHF₂, CF₃, CH₂ CF₃, CH₂ Cl, CCl₃, CHClMe, CH₂ CH₂ Cl, CHClCH₂ Cl, CH₂ Br, CHBrMe, CH₂ CH₂ Br, CH₂ OMe, CH₂ OEt, CH₂ OPr-n, CH₂ OPr-i, CH₂ OBu-n, CH₂ OBu-i, CH₂ OBu-s, CH₂ OBu-t, CHMeOMe, CHMiOEt, CHMeOPr-n, CHMeOPr-i, CHMeOBu-n, CHMeOBu-i, CHMeObu-s, CHMeOBu-t, CH₂ CH₂ OMe, CH₂ CH₂ OEt, CH₂ CH₂ OPr-i, Ac, COEt, COPr-n, COPr-i, COOMe, COOEt, COOPr-i, CONHMe, CONHEt, CONMe₂, CONEt₂, CONEtMe, OCHF₂, OCF₃, OCH₂ CF₃, SMe, SEt, CH₂ SMe, CH₂ SEt, CHMeSMe, CHMeSEt

Y: ##STR6## OCHMeCH═CH₂, OCMe₂ CH═CH₂, OCH₂ CMe═CH₂, OCH₂ CH═CHMe, OCH₂ CH═CMe₂, OCH₂ C.tbd.CH, OCHMeC.tbd.CH, OCHMe₂ C.tbd.CH, OCH₂ .tbd.CMe, OCH₂ CH₂ F, OCH₂ CHF₂, OCH₂ CF₃, OCH₂ CH₂ Cl, OCHMeCH₂ Cl, OCH₂ CCl₃, OCH₂ CH₂ CH₂ Cl, OCH₂ CH₂ Br, ##STR7## OCH₂ CCl═CH₂, OCH₂ CH₂ CH═CH₂, OCH₂ CCl═CHCl, OCH₂ CH₂ NO₂, OPh,OPh-Me-2 OPh-Cl-4, OPh-NO₂ -4, OPH₂ CH₂ OMe, OCH₂ CH₂ OEt, OCH₂ CH₂ OPr-n, OCH₂ CH₂ OPr-i, OCH₂ CH₂ OBu-n, OCH₂ CH₂ OBu-i, OCH₂ CH₂ Bu-s, OCH₂ CH₂ OBu-t, OCHMeCH₂ OMe, OCH₂ CH₂ OPh, OCH₂ CH₂ OCH₂ CH₂ OMe, OCH₂ CH₂ OH, OCH₂ CH₂ OCHMeCH₂ OMe, OCH₂ Ph, OCHMePh, OCH₂ Ph-4-Me, OCH₂ Ph-4-Cl, OCH₂ CH₂ Ph, ##STR8## OCH₂ CH₂ NH₂, OCH₂ CH₂ NHMe, OCH₂ CH₂ NMe₂, OCH₂ CH₂ NEt₂, OCH₂ COOMe, OCH₂ COOEt, OCH₂ COOPr-n, OCH₂ COOPr-i, OCH₂ COOBu-t, OCHMeCOOMe, OCHMeCOOEt OCHMeCOOPr-n, OCHMeCOOPr-i, OCHMeCOOBu-t OCH₂ CH₂ CN, OCH₂ CN, OCHMeCN, OCH₂ SMe, OCH₂ C(O)Ph, OCH₂ C(O)Me, OCH₂ CH₂ SMe, OCH₂ CH₂ SOMe, OCH₂ CH₂ SO₂ Me, OCH₂ CH₂ SEt, OCH₂ CH₂ SO₂ Et, OCOOMe, OCOOEt, OCOOPr-i, OCONH₂, OCONHMe, OCONMe₂, OP(O)(OMe)₂, OP(O)(OEt)₂, ##STR9## SCH₂ CH═CH₂, SCH₂ C.tbd.CH, SCH₂ CF₃, SCH₂ CH₂ Cl, SCH₂ CCl₃, ##STR10## SPh, SCH₂ CH₂ OMe, SCH₂ CH₂ OEt, SCH₂ CH₂ OPr-i, SCH₂ CH₂ OPh, ##STR11## S(O)CH₂ ═CH₂, S(O)CH₂ CH.tbd.CH,S(O)CH₂ CF₃, S(O)CH₂ CH₂ Cl, ##STR12## S(O)Ph, S(O)CH₂ CH₂ OMe, S(O)CH₂ CH₂ OEt, S(O)CH₂ CH₂ OPr-i, S(O)CH₂ CH₂ OPh, ##STR13## SO₂ CH₂ CH═CH₂, SO₂ CH₂ C.tbd.CH, SO₂ CH₂ CF₃, SO₂ CH₂ CH₂ Cl, SO₂ CH₂ ##STR14## SO₂ Ph, SO₂ CH₂ CH₂ OMe, SO₂ CH₂ CH₂ OEt, SO₂ CH₂ CH₂ OPr-i, Z : F, Cl, Br, I, NO₂, OMe, OEt, OPr-n, OPr-i, CF₃, CN, SMe, SOMe, SO₂ Me, SCF₃, SOCF₃, SO₂ CF₃ .

Q : H, Me, Et, n-Pr, i-Pr, n-Bu, i-Bu, s-Bu, t-Bu, CH₂ CH₂ Cl, CH₂ CF₃, CHClMe, CH₂ CH₂ Br, CHClCH₂ Cl, CH₂ CH═CH₂, CH₂ CME═CH₂, CH₂ CH═CHMe, CH₂ C.tbd.CH, CH₂ CCl═CH₂, CH₂ CN, CH₂ Ph, CH₂ Ph-Cl-2, CH₂ Ph-Cl-3, CH₂ Ph-Me-2, ##STR15## CH₂ Ph-Me₂ -2,4, CH₂ Ph-Me-4, CHMePh, CHEtPh, CH₂ Ph-NO₂ -2, CH₂ Ph-CF₃ -3, CH₂ OMe, CH₂ OEt, CH₂ OH, CHMeOH, CH₂ NHMe, CH₂ NMe₂, CHMeNM₂, CH₂ COPh, CH₂ COPh-NO₂ -4, CH₂ COPh-Me-4, CH₂ COPh-Cl-4, CH₂ COPh-Me₂ -2,4, CH₂ COPh-CF₃ -4, CH₂ Ac, CH₂ COEt, CHMeAc, CH₂ CO₂ Me, CH₂ CO₂ Et, CH₂ CO₂ Pr-n, CH₂ CO₂ Pr-i, CH₂ CO₂ Bu-t, CH₂ CO₂ H, CHMeCO₂ H, CH₂ CONHMe, CH₂ CONMe₂, CH₂ CONHEt, CH₂ CONEt₂, CH₂ CONPr-n₂, CH₂ OCH₂ CH═CH₂, CH₂ OAc, CH₂ COEt, CH₂ COPr-i, CH₂ COBu-t, CH₂ OCO₂ Me, CH₂ OCO₂ Et, CH₂ OCO₂ Pr-i, CH₂ OCO₂ Bu-t, CH₂ SMe, CH₂ SEt, CH₂ SCH₂ CH═CH₂, CH₂ SAc, CH₂ SCOBu-t, CH₂ SO₂ Me, CH₂ SO₂ Et, CH₂ SO₂ CH₂ CH═CH₂, CH₂ NHCH₂ CH═CH₂, CH₂ NMeCH₂ CH═CH₂, CH₂ NHAc, CH₂ NHCOEt, CH₂ NHCO₂ Me, CH₂ NHCO₂ Et, CH₂ NMeCO₂ Me, COPh, COPh-Me- 4, COPh-NO₂ -2, COPh-Cl₂ -2,4, Ac, COEt, COPr-n, COPr-i, COBu-n, COBu-t, COCH₂ Cl, COCHCl₂, COCCl₃, COCF₃, COCH₂ OMe, COCH₂ OPh, COCH₂ CH═CHCH₃, CO₂ Me, CO₂ Et, CO₂ Bu-t, CO₂ Pr-i, CONHMe, CONMe₂, CONHEt, CONEt₂, CONPr-n₂, CON(CH₂ CH═CH₂)₂, CONMePh, ##STR16## CO₂ CH₂ Ph, CO₂ Ph, SO₂ Me, SO₂ Et, SO₂ CH₂ CH═CH₂, SO₂ Ph, SO₂ Ph-Me-4, SO₂ Ph-Cl-4, SO₂ Ph-(NO₂)₂ -2,4 SO₂ CF₃, P(═O)(OMe)₂, P(═O)(OEt)₂, P(═O)(OPr-n)₂, P(═O)(OPr-i)₂, P(═S)(OMe)₂, P(═S)(OEt)₂, P(═O)OMeOPh, P(═O)(OCH₂ CH═CH₂)₂, P(═O)OPhOCH₂ CH═CH₂

When Q is a hydrogen atom, the compound may readily from a salt with a metal or with an organic base.

As such a metal, sodium, potassium, calcium, lithium, barium, magnesium, iron, copper, nickel or manganese may be mentioned.

As such an organic base, methylamine, dimethylamine, trimethylamine, ethylamine, diethylamine, triethylamine, n-propylamine, di-n-propylamine, i-propylamine, di-i-propylamine, n-butylamine, i-butylamine, sec-butylamine, tert-butylamine, piperidine, pyrrolidine, morpholine, pyridine, N,N-dimethylaniline or choline may be mentioned.

In the course of researches on the herbicidal properties of various organic compounds with an aim to develop useful herbicides, the present inventors have found that the above-mentioned compound of the present invention exhibits excellent herbicidal activities against narrow leaf weeds (gramineous and cyperaceous weeds) and against broad leaf weeds and no substantial phytotoxicity against useful plants e.g. crop plants such as Zea mays (corn), Sorghum bicolor (sorgo), Triticum spp (wheat) and Hordeum vulgare (barley). The present invention has been accomplished on the basis of this discovery.

The compound of the present invention exhibits strong herbicidal activities in each of soil treatment, soil incorporation treatment and foliage treatment. On the other hand, it exhibits no phytotoxicity against crop plants such as Zea mays, Sorghum bicolor, Triticum spp and Hordeum vulgare in a practical application in any of soil treatment, soil incorporation treatment and foliage treatment. Thus, the compound of the present invention has high selectivity and it is extremely effective for controlling weeds during the cultivation of these crop plants. Namely, the compound of the present invention exhibits strong herbicidal activities against noxious weeds such as Setaria viridis (green foxtail), Echinochloa crus-galli (barnyardgrass), Amarathus lividus (livid amaranth), Polvgonum longisetum (persicaria blumei gross), Xanthium strumarium (cocklebur), Abutilon theophrasti (velvet leaf) and Cyperus esculentus (yellow nutsedge), which develop during the cultivation of Zea mays or Sorphum bicolor. The herbicidal activities against gramineous weeds and Cyperus esculentus are remarkablly high and extremely unique. Heretofore, during the cultivation of Zea mays or Sorghum bicolor, it has been common to employ atranzine or cyanazine as a triazine-type herbicide, or alachlor or metolachlor as an acid anilide type herbicide. However, atranzine and cyanazine have poor herbicidal activities against gramineous weeds although they show high activities against broad leaf weeds, and their activities against Cyperus esculentus are very low. On the other hand, alachlor and metolachlor have poor activities against broad leaf weeds although their activities against gramineous weeds are high, and their activities against Cyperus esculentus are very poor. Thus, it has been difficult to eradicate all the weed species by a single application of such herbicides.

As a result of various studies, the present inventors have found the compound of the present invention which exhibits excellent herbicidal effects against a wide range of weeds, and the present invention has been accomplished on the basis of this discovery. The compound of the present invention also has a feature that it exhibits no phytotoxicity against crop plants such as Zea mays, Sorqhum bicolor, Triticum spp and Hordeum vulgare and thus can safely be applied to the fields for such crop plants.

Further, the compound of the present invention includes a compound which shows selectivity between Oryza sativa (rice) and Echinochloa crus-qalli (barnyardgrass), and it also includes a compound having selectivity for a useful plant such as Goxxypium spp (cotton), Beta vulgaris (sugar beat) or Clycine max (soybean).

Heretofore, it has been known that 4-benzoylpyrazole derivatives have excellent herbicidal activities. For example, pyrazolate (common name) is commercially available and widely used for practical application. However, such conventional herbicides are restricted in their application to paddy fields, and their activities are very poor in their application to upland fields. Whereas, as a result of extensive research for many years on 4-benzoylpyrazole derivatives, the present inventors have finally found that the compound of the present invention which simultaneously satisfies the various conditions for substituents in the structure as specified above, exhibits strong herbicidal activities in the application to upland fields in each of soil treatment, soil incorporation treatment and foliage treatment. It has been found that the compound of the present invention exhibits particularly high activities against gramineous weeds and Cyperus esculentus.

The compound of the present invention can readily be prepared by any one of the following reactions. ##STR17##

In the above formulas, A, B, V, W, X, Y, Z and Q are as defined above, E is a halogen atom, a methanesulfonyloxy group or a p-toluenesulfonyloxy group. Further, ##STR18## and may be represented by either formula.

Reaction scheme (1) represents a reaction wherein benzoic acid having suitable substituents and 5-hydroxypyrazole are reacted in an inert solvent in the presence of a condensation agent and a base to obtain 4-benzoyl-5-hydroxypyrazole. The condensation agent is used in an amount of from 1.0 to 1.5 mols per mol of the benzoic acid and pyrazole. As the condensation agent, N,N'-dicyclohexylcarbodiimide may be mentioned. The solvent may be any aolvent so long as it is inert to the reaction. Particularly preferred is tert-butyl alcohol, tert-amyl alcohol or isopropyl alcohol. The base may not necessarily be required. However, in general, the yield can be improved by using a base. There is no particular restriction as to the base, but potassium carbonate or sodium carbonate may preferably be employed. The reaction temperature may range from room temperature to boiling point of the solvent, but is peferably from 50° to 100° C.

The reaction time is usually from 0.5 to 20 hours.

Reaction scheme (2) shows a reaction wherein benzoyl chloride having suitable substituents and 5-hydroxypyrazole are reacted to form a benzoyl ester, which is then rearranged to a 4-benzoyl compound.

The benzoyl esterification can be accomplished in an inert solvent (such as an aromatic hydrocarbon, a fatty acid ester, a halogenated hydrocarbon, an ether, acetonitrile, dimethylsulfoxide or N,N'-dimethylformamide) or in a two phase system with such a solvent and water or in a mixture of such solvents in the presence of a suitable dehydrochlorinating agent (e.g. an inorganic base such as sodium hydroxide, potassium hydroxide or sodium hydrogencarbonate, or an organic base such as pyridine or triethylamine) at a temperature of from room temperature to 100° C. for from 10 minutes to 5 hours.

The rearrangement reaction can be accomplished by means of a Lewis acid such as anhydrous aluminum chloride or a base. As the base, potassium carbonate, calcium hydroxide or sodium carbonate may be used. The Lewis acid or base is used usually in an amount of from 1 to 10 mol times.

No solvent is required. However, in some cases, it is advantageous to use a solvent having a suitable boiling point to improve the operation efficiency or the yield. As such an advantageous example, use of dioxane, toluene or xylene diglyme, may be mentioned.

The reaction temperature is usually from 50° to 150° C., and the reaction time is usually from 15 minutes to 30 hours.

Reaction scheme (3) shows a reaction wherein a benzene derivative, a 5-hydroxypyrazole derivative and carbon tetrachloride are condensed in the presence of a Lewis acid in an inert solvent or in the absence of a solvent, followed by hydrolysis to obtain a 4-benzoyl-5-hydroxypyrazole derivative. As the Lewis acid, anhydrous aluminum chloride or anhydrous aluminum bromide in an amount of at least the theoretical amount for the reaction is preferred. The solvent may be of any type so long as it is inert to the reaction. However, a chlorine-type solvent such as methylene chloride, dichloroethane or tetrachloroethane is preferred. The temperature for condensation may range from 0° C. to the boiling point of the solvent, but it is preferably from 10° to 80° C. The hydrolysis is conducted in the presence of hydrochloric acid or sulfuric acid. The temperature for the hydrolysis is preferably from room temperature to 100° C. The time for the hydrolysis is usually from 0.1 to 10 hours.

Reaction scheme (4) shows a reaction wherein a benzoyl cyanide derivative and a 5-hydroxypyrazole derivative are reacted in the presence of a Lewis acid and a base in an inert solvent or in the absence of a solvent to obtain a 4-benzoyl-5-hydroxypyrazole. As the Lewis acid, zinc chloride, aluminum chloride or aluminum bromide may be used. As the base, pyridine or triethylamine may be mentioned. The Lewis acid and the base are used usually in an amount of from 1 to 10 mol times. As the solvent, methylene chloride, dichloroethane or tetrachloroethane may be mentioned. The reaction temperature is usually from 0° to 80° C., preferably from 10° to 50° C. The reaction time is from 0.5 to 20 hours.

Reaction scheme (5) shows a reaction wherein 4-benzoyl-5-hydroxyyrazole is condensed with a halide, a methanesulfonic acid ester or a p-toluenesulfonic acid ester.

For this reaction, it is preferred to employ from 1 to 3 mol times of a dehydrohalogenating agent. As such a dehydrohalogenating agent, an inorganic base such as sodium hydroxide, potassium hydroxide, sodium carbonate, sodium hydrogencarbonate or potassium carbonate, or an organic base such as pyridine or triethylaine, may be mentioned.

There is no particular restriction as to the solvent so long as it is inert to the reaction. A wide range of solvents including an aromatic hydrocarbon, a fatty acid ester, a halogenated hydrocarbon, an ether, a ketone, an aliphatic hydrocarbon, acetonitrile, dimethylsulfoxide and dimethylformamide may be used.

The reaction temperature may be optionally selected within a range of from room temperature to the boiling point of the solvent. The reaction time is usually from 30 minutes to 30 hours.

Reaction scheme (6) shows a reaction wherein 4-benzoyl-5-hydroxypyrazole is converted to a 5 halogeno compound by a halogenating agent, or to a methanesulfonate compound or a p-toluenesulfonate compound by methane sulfonyl chloride or p-toluenesulfonyl chloride, followed by condensation with a suitable alcohol or acid.

As the halogenating agent, phosphorus oxychloride, phosphorus pentachloride or thionyl chloride may be mentioned.

As the solvent, a wide range of solvents inert to the reaction, such as dimethylformamide, may be employed. However, the reaction can be conducted without any solvent.

The reaction temperature is preferably from 30° to 150° C, and the reaction time is usually from 30 minutes to 10 hours. In some cases, the reaction time may be shortened or the yield may be improved by an addition of a dehydrohalogenating agent.

The condensation reaction with an alcohol or acid is conducted by an addition of a dehydrohalogenating agent.

As such a dehydrohalogenating agent, a base such as sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, sodium alkoxide or sodium hydride may be employed.

The solvent may be any solvent which is inert to the reaction (such as an aromatic hydrocarbon, an ether, a ketone or N,N'-dimethylformamide). The reaction temperature may be selected within a range of from room temperature to the boiling point of the solvent.

The substituted benzene derivatives used as the starting materials for the compounds of the present invention have novel structures, and they may readily be prepared by a proper combination of various known syntheses. For instance, compounds wherein the substituent Z in the benzene ring is --S(O)_(n) CH₃ can be prepared in accordance with the following reaction schemes. ##STR19##

In the above formulas, X and Y are as defined above, and Hal is a halogen atom.

Now, the preparation of the substituted benzene derivatives and pyrazole derivatives will be described in detail with reference to Examples. However, it should be understood that the present invention is by no means restricted by such specific Examples.

EXAMPLE 1 Preparation of 4-(2-chloro-4-methanesulfonyl-3-(2-methoxy)ethoxybenzoyl)-1-ethyl-5-hydroxypyrazole (1) (2-methoxy)ethyl 2-chloro-4-methanesulfonyl-3-(2-methoxy)ethoxybenzoate

1.2 g of 2-chloro-3-hydroxy-4-methanesulfonylbenzoic acid, 1.4 g of potassium carbonate and 2.1 g of 2bromoethyl methyl ether were put into 20 ml of N,N-dimethylformamide and reacted under heating at a temperture of from 60° to 70° C. for from 6 to 7 hours. Then, the solvent was distilled off, and after an addition of water, the reaction mixture was extracted with chloroform. The extract was dried over anhydrous sodium sulfate, and the solvent was distilled off to obtain 1.9 g of a crude product of the above identified compound.

(2) 2 -chloro-4-methanesulfonyl-3-(2-methoxy)ethoxybenzoic acid

1.9 g of the crude product of (2-methoxy)ethyl 2-chloro-4-methanesulfonyl-3-(2-methoxy)ethoxybenzoate was dissolved in 50 ml of ethanol, and 20 ml of an aqueous solution containing 1 g of sodium hydroxide was added thereto. The mixture was stirred at room temperature for 30 minutes. Then, ethanol was distilled off, and water was added to the residue. The mixture was washed with chloroform, then acidified with concentrated hydrochloric acid and extracted with chloroform. The extract was dried over anhydrous sodium sulfate. Then, the solvent was distilled off to obtain 1.4 g of a crude product of the above identified compound. To the crude product, n-hexane was added, and the mixture was left to stand, whereby the desired product was gradually crystallized. Melting point: 89°-92° C.

(3) 4-(2-chloro-4-methanesulfonyl-3-(2-methoxy)ethoxybenzoyl)-1-ethyl-5-hydroxypyrazole

1.2 g of the crude product of 2-chloro-4-methanesulfonyl-3-(2-methoxy)ethoxybenzoic acid, 0.3 g of potassium carbonate, 0.45 g of 1-ethyl-5-hydroxypyrazole and 0.77 g of N,N'-dicyclohexyl carbodiimide were put into 40 ml of t-amyl alcohol, and the mixture was stirred under heating at a temperature of from 80° to 90° C. for from 4 to 5 hours. The solvent was distilled off, and a dilute potassium carbonate aqueous solution was added to the residue. The mixture was washed with chloroform. The aqueous layer was acidified with concentrated hydrochloric acid and extracted with chloroform. The extract was dried over anhydrous sodium sulfate. Then, the solvent was distilled off to obtain a crude product of the above identified compound. The crude product was recrystallized from ethanol to obtain 0.3 g of the desired product. Melting point: 159°-160° C.

EXAMPLE 2 Preparation of 4-(3-benzyloxy-2-chloro-4-methanesulfonylbenzoyl)-1-ethyl-5-hydroxypyrazole (1}Benzyl 3-benzyloxy-2-chloro-4-methanesulfonylbenzoate

1.5 g of 2-chloro-3-hydroxy-4-methanesulfonylbenzoic acid, 1.7 g of potassium carbonate and 5.1 g of benzyl bromide were put into 50 ml of dimethylformamide, and the mixture was stirred at room temperature overnight and then heated at a temperature of from 60° to 70° C. for 3 hours. The solvent was distilled off, and water was added to the residue. The mixture was extracted with chloroform. The extract was dried over anhydrous sodium sulfate. Then, the solvent was distilled off to obtain a crude product of the above identified compound. The crude product was recrystallized from ethanol to obtain 2.5 g of the desired product.

(2) 3-benzyloxy-2-chloro-4-methanesulfonylbenzoic acid

2.5 g of benzyl 3-benzyloxy-2-chloro-4-methanesulfonylbenzoate was put into 50 ml of ethanol, and 25 ml of an aqueous solution containing 1 g of sodium hydrochloride was added thereto. The mixture was stirred at room temperature for 30 minutes. Then, ethanol was distilled off, and water was added to the residue. The mixture was washed with chloroform. The aqueous layer was acidified with concentrated hydrochloric acid and then extracted with chloroform. The extract was dried over anhydrous sodium sulfate. Then, the solvent was distilled off to obtain a crude product of the above identified compound. The crude product was washed with ethanol-isopropyl ether to obtain 1.0 g of the desired product.

(3)-4-(3-benzyloxy-2-chloro-4-methanesulfonylbenzol)-ethyl-5-hydroxypyrazol

1.0 g of 3-benzyloxy-2-chloro-4methanesulfonylbenzoic acid, 0.23 g of potassium carbonate, 0.24 g of 1-ethyl-5-hydroxy-pyrazole and 0.59 g of N,N'-dicyclohexylcarbodiimide were put into 20 ml of t-amyl alcohol, and the mixture was stirred under heating at a temperature of from 80° to 90° C. for 4 hours. The solvent was distilled off, and then an aqueous potassium carbonate solution was added to the residue. The mixture was washed with chloroform. The aqueous layer was acidified with concentrated hydrochloric acid and then extracted with chloroform. The extract was dried over anhydrous sodium sulfate. Then, the solvent was distilled off to obtain a crude product of the above identified compound. The crude product was recrystallized from ethanol to obtain 0.3 g of the desired product. Melting point: 162°-165° C.

The physical properties of the benzoic acids and the pyrazole derivatives prepared in accordance with the preceeding Examples will be given in Tables 1 and 2 including those of the preceeding Examples.

                  TABLE 1                                                          ______________________________________                                          ##STR20##                                                                                                     Melting                                        X      Y                Z       point (°C.)                             ______________________________________                                         Cl                                                                                     ##STR21##       SO.sub.2 Me                                                                            102˜107                                  Cl     OCH.sub.2 CH.sub.2 OPh                                                                          SO.sub.2 Me                                                                            147˜151                                  Cl                                                                                     ##STR22##       SO.sub.2 Me                                                                            153˜157                                  Cl     OCH.sub.2 CH.sub.2 CHCH.sub.2                                                                   SO.sub.2 Me                                                                            90˜94                                    Cl     OCH.sub.2 CHCHMe SO.sub.2 Me                                                                            113˜118                                  Cl     OCH.sub.2 CH.sub.2 OMe                                                                          SO.sub.2 Me                                                                            89˜92                                    ______________________________________                                    

                                      TABLE 2                                      __________________________________________________________________________      ##STR23##                                                                     Compound                        Melting                                        No.   A  B  X Y           Z   Q point (°C.)                             __________________________________________________________________________      1    Et H  Cl                                                                               OCH.sub.2 CH.sub.2 OMe                                                                     SO.sub.2 Me                                                                        H 159˜160                                   2    Et H  Cl                                                                               OCH.sub.2 Ph                                                                               SO.sub.2 Me                                                                        H 162˜165                                   3    Et H  Cl                                                                                ##STR24##  SO.sub.2 Me                                                                        H 156˜159                                   4    Et H  Cl                                                                                ##STR25##  SO.sub.2 Me                                                                        H 153˜157                                   5    Et H  Cl                                                                               OCH.sub.2 CH.sub.2 OPh                                                                     SO.sub.2 Me                                                                        H 148˜150                                   6    Et H  Cl                                                                               OCH.sub.2 CCH                                                                              SO.sub.2 Me                                                                        H 150.7˜152.4                               7    Et H  Cl                                                                               OCH.sub.2 CH.sub.2 OEt                                                                     SO.sub.2 Me                                                                        H 152.3˜154.9                               8    Et H  Cl                                                                               OCH.sub.2 CH.sub.2 CHCH.sub.2                                                              SO.sub.2 Me                                                                        H 131˜134                                   9    Et H  Cl                                                                               OCH.sub.2 CH.sub.2 SMe                                                                     SO.sub.2 Me                                                                        H Oily substance                                 10    Et H  Cl                                                                               OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                             SO.sub.2 Me                                                                        H 206˜208                                  11    Et H  Cl                                                                               OCH.sub.2 CH.sub.2 OPr-i                                                                   SO.sub.2 Me                                                                        H 171˜174                                  12    Et H  Cl                                                                                ##STR26##  SO.sub.2 Me                                                                        H 191˜193                                  13    Me Me Cl                                                                                ##STR27##  SO.sub.2 Me                                                                        H   181˜183.5                              14    Et H  Cl                                                                                ##STR28##  SO.sub.2 Me                                                                        H 100˜101                                  15    Et H  Cl                                                                                ##STR29##  SO.sub.2 Me                                                                        H 171˜173                                  16    Me Me Cl                                                                                ##STR30##  SO.sub.2 Me                                                                        H 138˜142                                  17    Me Me Cl                                                                                ##STR31##  SO.sub.2 Me                                                                        H 100.5˜101                                18    Et H  Cl                                                                                ##STR32##  SO.sub.2 Me                                                                        H 154˜158                                  19    Et H  Cl                                                                                ##STR33##  SO.sub.2 Me                                                                        H 175˜179                                  20    i-Pr                                                                              H  Cl                                                                               OCH.sub.2 CH.sub.2 OMe                                                                     SO.sub.2 Me                                                                        H 180˜183                                  __________________________________________________________________________

Compounds which can be prepared in the same manner as the preceding Examples will be given in Tables 3 to 8 including those of the preceding Examples. However, the present invention is not restricted to such compounds.

Various symbols used in Tables 3 to 8 have the following meanings. ##STR34##

                  TABLE 3                                                          ______________________________________                                         X      Y                  Z        Q                                           ______________________________________                                         Me     Y1                 SO.sub.2 Me                                                                             H                                           Me     Y2                 SO.sub.2 Me                                                                             H                                           Me     Y3                 SO.sub.2 Me                                                                             H                                           Me     Y4                 SO.sub.2 Me                                                                             H                                           Me     Y5                 SO.sub.2 Me                                                                             H                                           Me     Y6                 SO.sub.2 Me                                                                             H                                           Me     Y7                 SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                             H                                           Me     OCHMeCHCH.sub.2    SO.sub.2 Me                                                                             H                                           Me     OCMe.sub.2 CHCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CMeCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CHCHMe   SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 CHCH.sub.2                                                                     SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CCH      SO.sub.2 Me                                                                             H                                           Me     OCHMeC CH          SO.sub.2 Me                                                                             H                                           Me     OCMe.sub.2 CCH     SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CCMe     SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 F                                                                              SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           Me     OCHMeCH.sub.2 Cl   SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                             H                                           Me     Y8                 SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CClCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CClCHCl  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 NO.sub.2                                                                       SO.sub.2 Me                                                                             H                                           Me     OPh                SO.sub.2 Me                                                                             H                                           Me     OPhMe-2            SO.sub.2 Me                                                                             H                                           Me     OPhCl-4            SO.sub.2 Me                                                                             H                                           Me     OPhNO.sub.2 -4     SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2Y4                                                                              SO.sub.2 Me                                                                             H                                           Me     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OPr-i                                                       SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 Ph       SO.sub.2 Me                                                                             H                                           Me     OCHMePh            SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 Ph                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 Ph-4-OMe SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                             H                                           Me     Y9                 SO.sub.2 Me                                                                             H                                           Me     Y10                SO.sub.2 Me                                                                             H                                           Me     Y11                SO.sub.2 Me                                                                             H                                           Me     Y12                SO.sub.2 Me                                                                             H                                           Me     Y13                SO.sub.2 Me                                                                             H                                           Me     Y14                SO.sub.2 Me                                                                             H                                           Me     Y15                SO.sub.2 Me                                                                             H                                           Me     Y16                SO.sub.2 Me                                                                             H                                           Me     Y17                SO.sub.2 Me                                                                             H                                           Me     Y18                SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 NME.sub.2                                                                      SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                             H                                           Me     Y19                SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 COOMe    SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 COOEt    SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 COOY4    SO.sub.2 Me                                                                             H                                           Me     OCHMeCOOMe         SO.sub.2 Me                                                                             H                                           Me     OCHMeCOOEt         SO.sub.2 Me                                                                             H                                           Me     OCHMeCOOPr-i       SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 SMe      SO.sub. 2 Me                                                                            H                                           Me     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             H                                           Me     OCOOMe             SO.sub.2 Me                                                                             H                                           Me     OCOOPr-i           SO.sub.2 Me                                                                             H                                           Me     OCONH.sub.2        SO.sub.2 Me                                                                             H                                           Me     OCONHMe            SO.sub.2 Me                                                                             H                                           Me     OCONMe.sub.2       SO.sub.2 Me                                                                             H                                           Me     OP(O)(OMe).sub.2   SO.sub.2 Me                                                                             H                                           Me     Y20                SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CCH      SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           Me     Y21                SO.sub.2 Me                                                                             H                                           Me     SPh                SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           Me     Y22                SO.sub.2 Me                                                                             H                                           Me     S(O)CH.sub.2 CHCH.sub.2                                                                           SO.sub.2 Me                                                                             H                                           Me     S(O)CH.sub.2 CHCMe.sub.2                                                                          SO.sub.2 Me                                                                             H                                           Me     S(O)CH.sub.2 CCH   SO.sub.2 Me                                                                             H                                           Me     S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                             H                                           Me     Y23                SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CHCMe.sub.2                                                                     SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CCH                                                                             SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                             H                                           Me     Y24                SO.sub.2 Me                                                                             H                                           Me     Y25                SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 Ph        SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CH.sub.2 OEt                                                                    SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub. 2 Ph                                Me     OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     SO.sub.2 CH.sub.2 OPr-i                                                                           SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     OCH.sub. 2 CH.sub.2 SOMe                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           Me     OCH.sub.2 CH.sub.2 OEt                                                                            Cl       H                                           Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl       H                                           Me     OCHMeCH.sub.2 OMe  Cl       H                                           Me     OCH.sub.2 COOMe    Cl       H                                           Me     OCH.sub.2 CH.sub.2 SMe                                                                            Cl       H                                           Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       H                                           Me     SCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       H                                           Me     OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 SMe                                                                            Cl       CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 SOMe                                                                           Cl       CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 Ph                                 Me     SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 SMe                                                                            Cl       CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 COPh                               Me     SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               Me     SCH.sub.2 CH.sub.2 OEt                                                                            Cl       CH.sub.2 COPh                               Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 COPh                               Cl     Y1                 SO.sub.2 Me                                                                             H                                           Cl     Y2                 SO.sub.2 Me                                                                             H                                           Cl     Y3                 SO.sub.2 Me                                                                             H                                           Cl     Y4                 SO.sub.2 Me                                                                             H                                           Cl     Y5                 SO.sub.2 Me                                                                             H                                           Cl     Y6                 SO.sub.2 Me                                                                             H                                           Cl     Y7                 SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                             H                                           Cl     OCHMeCHCH.sub.2    SO.sub.2 Me                                                                             H                                           Cl     OCMe.sub.2 CHCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CMeCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CHCHMe   SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 CHCH.sub.2                                                                     SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CCH      SO.sub.2 Me                                                                             H                                           Cl     OCHMeCCH           SO.sub.2 Me                                                                             H                                           Cl     OCMe.sub.2 CCH     SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CCMe     SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 F                                                                              SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           Cl     OCHMeCH.sub.2 Cl   SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                    SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                             H                                           Cl     Y8                 SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CClCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CClCHCl  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 NO.sub.2                                                                       SO.sub.2 Me                                                                             H                                           Cl     OPh                SO.sub.2 Me                                                                             H                                           Cl     OPhMe-2            SO.sub.2 Me                                                                             H                                           Cl     OPhCl-4            SO.sub.2 Me                                                                             H                                           Cl     OPhNO.sub.2 -4     SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2Y4                                                                              SO.sub.2 Me                                                                             H                                           Cl     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OPr-i                                                       SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 Ph       SO.sub.2 Me                                                                             H                                           Cl     OCHMePh            SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 Ph                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 Ph-4-OMe SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                             H                                           Cl     Y9                 SO.sub.2 Me                                                                             H                                           Cl     Y10                SO.sub.2 Me                                                                             H                                           Cl     Y11                SO.sub.2 Me                                                                             H                                           Cl     Y12                SO.sub.2 Me                                                                             H                                           Cl     Y13                SO.sub.2 Me                                                                             H                                           Cl     Y14                SO.sub.2 Me                                                                             H                                           Cl     Y15                SO.sub.2 Me                                                                             H                                           Cl     Y16                SO.sub.2 Me                                                                             H                                           Cl     Y17                SO.sub.2 Me                                                                             H                                           Cl     Y18                SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 NMe.sub.2                                                                      SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                             H                                           Cl     Y19                SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 COOMe    SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 COOEt    SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 COOY4    SO.sub.2 Me                                                                             H                                           Cl     OCHMeCOOMe         SO.sub.2 Me                                                                             H                                           Cl     OCHMeCOOEt         SO.sub.2 Me                                                                             H                                           Cl     OCHMeCOOPr-i       SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 SMe      SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             H                                           Cl     OCOOMe             SO.sub.2 Me                                                                             H                                           Cl     OCOOPr-i           SO.sub.2 Me                                                                             H                                           Cl     OCONH.sub.2        SO.sub.2 Me                                                                             H                                           Cl     OCONHMe            SO.sub.2 Me                                                                             H                                           Cl     OCONMe.sub.2       SO.sub.2 Me                                                                             H                                           Cl     OP(O)(OMe).sub.2   SO.sub.2 Me                                                                             H                                           Cl     Y20                SO.sub.2 Me                                                                             H                                           Cl     SCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                             H                                           Cl     SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Cl     SCH.sub.2 CCH      SO.sub.2 Me                                                                             H                                           Cl     SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           Cl     SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           Cl     Y21                SO.sub.2 Me                                                                             H                                           Cl     SPh                SO.sub.2 Me                                                                             H                                           Cl     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           Cl     SCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             H                                           Cl     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           Cl     Y22                SO.sub.2 Me                                                                             H                                           Cl     S(O)CH.sub.2 CHCH.sub.2                                                                           SO.sub.2 Me                                                                             H                                           Cl     S(O)CH.sub.2 CHCMe.sub.2                                                                          SO.sub.2 Me                                                                             H                                           Cl     S(O)CH.sub.2 CCH   SO.sub.2 Me                                                                             H                                           Cl     S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                             H                                           Cl     Y23                SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 CHCMe.sub.2                                                                     SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 CCH                                                                             SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                             H                                           Cl     Y24                SO.sub.2 Me                                                                             H                                           Cl     Y25                SO.sub.2 Me                                                                             H                                           Cl     SO.sub. 2 Ph       SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 CH.sub.2 OEt                                                                    SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             CH.sub. 2 Ph                                Cl     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 SOMe                                                                           SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           Cl     OCH.sub.2 CH.sub.2 OEt                                                                            Cl       H                                           Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl       H                                           Cl     OCHMeCH.sub.2 OMe  Cl       H                                           Cl     OCH.sub.2 COOMe    Cl       H                                           Cl     OCH.sub.2 CH.sub.2 SMe                                                                            Cl       H                                           Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       H                                           Cl     SCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       H                                           Cl     OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 SMe                                                                            Cl       CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 SOMe                                                                           Cl       CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 Ph                                 Cl     SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 SMe                                                                            Cl       CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 COPh                               Cl     SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               Cl     SCH.sub.2 CH.sub.2 OEt                                                                            Cl       CH.sub.2 COPh                               Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 COPh                               OMe    Y1                 SO.sub.2 Me                                                                             H                                           OMe    Y2                 SO.sub.2 Me                                                                             H                                           OMe    Y3                 SO.sub.2 Me                                                                             H                                           OMe    Y4                 SO.sub.2 Me                                                                             H                                           OMe    Y5                 SO.sub.2 Me                                                                             H                                           OMe    Y6                 SO.sub.2 Me                                                                             H                                           OMe    Y7                 SO.sub.2 Me                                                                             H                                           OMe    OCH.sub. 2 CHCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCHMeCHCH.sub.2    SO.sub.2 Me                                                                             H                                           OMe    OCMe.sub.2 CHCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CMeCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CHCHMe   SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 CHCH.sub.2                                                                     SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CCH      SO.sub.2 Me                                                                             H                                           OMe    OCHMeCCH           SO.sub.2 Me                                                                             H                                           OMe    OCMe.sub.2 CCH     SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CCMe     SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 F                                                                              SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           OMe    OCHMeCH.sub.2 Cl   SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                    SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                             H                                           OMe    Y8                 SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CClCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CClCHCl  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 NO.sub.2                                                                       SO.sub.2 Me                                                                             H                                           OMe    OPh                SO.sub.2 Me                                                                             H                                           OMe    OPhMe-2            SO.sub.2 Me                                                                             H                                           OMe    OPhCl-4            SO.sub.2 Me                                                                             H                                           OMe    OPhNO.sub.2 -4     SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 -Y4                                                                            SO.sub.2 Me                                                                             H                                           OMe    OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OPr-i                                                       SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 Ph       SO.sub.2 Me                                                                             H                                           OMe    OCHMePh            SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 Ph                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 Ph-4-OMe SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                             H                                           OMe    Y9                 SO.sub.2 Me                                                                             H                                           OMe    Y10                SO.sub.2 Me                                                                             H                                           OMe    Y11                SO.sub.2 Me                                                                             H                                           OMe    Y12                SO.sub.2 Me                                                                             H                                           OMe    Y13                SO.sub.2 Me                                                                             H                                           OMe    Y14                SO.sub.2 Me                                                                             H                                           OMe    Y15                SO.sub.2 Me                                                                             H                                           OMe    Y16                SO.sub.2 Me                                                                             H                                           OMe    Y17                SO.sub.2 Me                                                                             H                                           OMe    Y18                SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 NMe.sub.2                                                                      SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                             H                                           OMe    Y19                SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 COOMe    SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 COOEt    SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 COO-Y4   SO.sub.2 Me                                                                             H                                           OMe    OCHMeCOOMe         SO.sub.2 Me                                                                             H                                           OMe    OCHMeCOOEt         SO.sub.2 Me                                                                             H                                           OMe    OCHMeCOOPr-i       SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 SMe      SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             H                                           OMe    OCOOMe             SO.sub.2 Me                                                                             H                                           OMe    OCOOPr-i           SO.sub.2 Me                                                                             H                                           OMe    OCONH.sub.2        SO.sub.2 Me                                                                             H                                           OMe    OCONHMe            SO.sub.2 Me                                                                             H                                           OMe    OCONMe.sub.2       SO.sub.2 Me                                                                             H                                           OMe    OP(O)(OMe).sub.2   SO.sub.2 Me                                                                             H                                           OMe    Y20                SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CCH      SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           OMe    Y21                SO.sub.2 Me                                                                             H                                           OMe    SPh                SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           OMe    Y22                SO.sub.2 Me                                                                             H                                           OMe    S(O)CH.sub.2 CHCH.sub.2                                                                           SO.sub.2 Me                                                                             H                                           OMe    S(O)CH.sub.2 CHCMe.sub.2                                                                          SO.sub.2 Me                                                                             H                                           OMe    S(O)CH.sub.2 CCH   SO.sub.2 Me                                                                             H                                           OMe    S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                             H                                           OMe    Y23                SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 CH.sub.2 CHCMe.sub.2                                                                     SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 CH.sub. 2 CCH                                                                            SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                             H                                           OMe    Y24                SO.sub.2 Me                                                                             H                                           OMe    Y25                SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 Ph        SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 CH.sub.2 CH.sub.2 OEt                                                                    SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 SOMe                                                                           SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           OMe    OCH.sub.2 CH.sub.2 OEt                                                                            Cl       H                                           OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl       H                                           OMe    OCHMeCH.sub.2 OMe  Cl       H                                           OMe    OCH.sub.2 COOMe    Cl       H                                           OMe    OCH.sub.2 CH.sub.2 SMe                                                                            Cl       H                                           OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       H                                           OMe    SCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       H                                           OMe    OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 SMe                                                                            Cl       CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 SOMe                                                                           Cl       CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 Ph                                 OMe    SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 SMe                                                                            Cl       CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 COPh                               OMe    SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               OMe    SCH.sub.2 CH.sub.2 OEt                                                                            Cl       CH.sub.2 COPh                               OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 COPh                               CH.sub.2 OMe                                                                          Y1                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y2                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y3                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y4                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y5                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y6                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y7                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMeCHCH.sub.2    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCMe.sub.2 CHCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CMeCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CHCHMe   SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 CHCH.sub.2                                                                     SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CCH      SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMeCCH           SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCMe.sub.2 C CH    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CCMe     SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 F                                                                              SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMeCH.sub.2 Cl   SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y8                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CClCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CClCHCl  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NO.sub.2                                                                       SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OPh                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OPhMe-2            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OPhCl-4            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OPhNO.sub.2 -4     SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 -Y4                                                                            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OPr-i                                                       SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 Ph       SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMePh            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 Ph                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 Ph-4-OMe SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y9                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y10                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y11                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y12                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y13                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y14                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y15                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y16                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y17                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y18                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NMe.sub.2                                                                      SO.sub.2 Me                                                                             H                                           CH.sub. 2 OMe                                                                         OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y19                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 COOMe    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 COOEt    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 COO-Y4   SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMeCOOMe         SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMeCOOEt         SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMeCOOPr-i       SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 SMe      SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCOOMe             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCOOPr-i           SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCONH.sub.2        SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCONHMe            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCONMe.sub.2       SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OP(O)(OMe).sub.2   SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y20                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CCH      SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y21                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SPh                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y22                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          S(O)CH.sub.2 CHCH.sub.2                                                                           SO.sub.2 Me                                                                             H                                           CH.sub. 2 OMe                                                                         S(O)CH.sub.2 CHCMe.sub.2                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          S(O)CH.sub.2 CCH   SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y23                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CHCMe.sub.2                                                                     SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CCH                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y24                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 Ph        SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OEt                                                                    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub. 2 Ph                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SOMe                                                                           SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OEt                                                                            Cl       H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl       H                                           CH.sub.2 OMe                                                                          OCHMeCH.sub.2 OMe  Cl       H                                           CH.sub.2 OMe                                                                          OCH.sub.2 COOMe    Cl       H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            Cl       H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            Cl       CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SOMe                                                                           Cl       CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            Cl       CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 COPh                               CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OEt                                                                            Cl       CH.sub.2 COPh                               CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 COPh                               ______________________________________                                    

                  TABLE 4                                                          ______________________________________                                         ; -                                                                             ##STR35##                                                                     X      Y                  Z       Q                                            ______________________________________                                         Me     Y1                 SO.sub.2 Me                                                                            H                                            Me     Y2                 SO.sub.2 Me                                                                            H                                            Me     Y3                 SO.sub.2 Me                                                                            H                                            Me     Y4                 SO.sub.2 Me                                                                            H                                            Me     Y5                 SO.sub.2 Me                                                                            H                                            Me     Y6                 SO.sub.2 Me                                                                            H                                            Me     Y7                 SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                            H                                            Me     OCHMeCHCH.sub.2    SO.sub.2 Me                                                                            H                                            Me     OCMe.sub.2 CHCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CMeCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CHCHMe   SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 CHCH.sub.2                                                                     SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CCH      SO.sub.2 Me                                                                            H                                            Me     OCHMeC CH          SO.sub.2 Me                                                                            H                                            Me     OCMe.sub.2 CCH     SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CCMe     SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 F                                                                              SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            Me     OCHMeCH.sub.2 Cl   SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                    SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                            H                                            Me     Y8                 SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CClCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CClCHCl  SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 NO.sub.2                                                                       SO.sub.2 Me                                                                            H                                            Me     OPh                SO.sub.2 Me                                                                            H                                            Me     OPhMe-2            SO.sub.2 Me                                                                            H                                            Me     OPhCl-4            SO.sub.2 Me                                                                            H                                            Me     OPhNO.sub.2 -4     SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2Y4                                                                              SO.sub.2 Me                                                                            H                                            Me     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OPr-i                                                       SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 Ph       SO.sub.2 Me                                                                            H                                            Me     OCHMePh            SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 Ph                                                                             SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 Ph-4-OMe SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                            H                                            Me     Y9                 SO.sub.2 Me                                                                            H                                            Me     Y10                SO.sub.2 Me                                                                            H                                            Me     Y11                SO.sub.2 Me                                                                            H                                            Me     Y12                SO.sub.2 Me                                                                            H                                            Me     Y13                SO.sub.2 Me                                                                            H                                            Me     Y14                SO.sub.2 Me                                                                            H                                            Me     Y15                SO.sub.2 Me                                                                            H                                            Me     Y16                SO.sub.2 Me                                                                            H                                            Me     Y17                SO.sub.2 Me                                                                            H                                            Me     Y18                SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 NMe.sub.2                                                                      SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                            H                                            Me     Y19                SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 COOMe    SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 COOEt    SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 COOY4    SO.sub.2 Me                                                                            H                                            Me     OCHMeCOOMe         SO.sub.2 Me                                                                            H                                            Me     OCHMeCOOEt         SO.sub.2 Me                                                                            H                                            Me     OCHMeCOOPr-i       SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 SMe      SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            H                                            Me     OCOOMe             SO.sub.2 Me                                                                            H                                            Me     OCOOPr-i           SO.sub.2 Me                                                                            H                                            Me     OCONH.sub.2        SO.sub.2 Me                                                                            H                                            Me     OCONHMe            SO.sub.2 Me                                                                            H                                            Me     OCONMe.sub.2       SO.sub.2 Me                                                                            H                                            Me     OP(O)(OMe).sub.2   SO.sub.2 Me                                                                            H                                            Me     Y20                SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 CCH      SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            Me     Y21                SO.sub.2 Me                                                                            H                                            Me     SPh                SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            Me     Y22                SO.sub.2 Me                                                                            H                                            Me     S(O)CH.sub.2 CHCH.sub.2                                                                           SO.sub.2 Me                                                                            H                                            Me     S(O)CH.sub.2 CHCMe.sub.2                                                                          SO.sub.2 Me                                                                            H                                            Me     S(O)CH.sub.2 CCH   SO.sub.2 Me                                                                            H                                            Me     S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                            H                                            Me     Y23                SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 CHCMe.sub.2                                                                     SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 CCH                                                                             SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                            H                                            Me     Y24                SO.sub.2 Me                                                                            H                                            Me     Y25                SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 Ph        SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 CH.sub.2 OEt                                                                    SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub. 2 Me                                                                           H                                            Me     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 SOMe                                                                           SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            Me     OCH.sub.2 CH.sub.2 OEt                                                                            Cl      H                                            Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl      H                                            Me     OCHMeCH.sub.2 OMe  Cl      H                                            Me     OCH.sub.2 COOMe    Cl      H                                            Me     OCH.sub.2 CH.sub.2 SMe                                                                            Cl      H                                            Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      H                                            Me     SCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      H                                            Me     OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 SOMe                                                                           Cl      CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 Ph                                  Me     SCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 COPh                                Me     SCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                Me     SCH.sub.2 CH.sub.2 OEt                                                                            Cl      CH.sub.2 COPh                                Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 COPh                                Cl     Y1                 SO.sub.2 Me                                                                            H                                            Cl     Y2                 SO.sub.2 Me                                                                            H                                            Cl     Y3                 SO.sub.2 Me                                                                            H                                            Cl     Y4                 SO.sub.2 Me                                                                            H                                            Cl     Y5                 SO.sub.2 Me                                                                            H                                            Cl     Y6                 SO.sub.2 Me                                                                            H                                            Cl     Y7                 SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                            H                                            Cl     OCHMeCHCH.sub.2    SO.sub.2 Me                                                                            H                                            Cl     OCMe.sub.2 CHCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CMeCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CHCHMe   SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 CHCH.sub.2                                                                     SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CCH      SO.sub.2 Me                                                                            H                                            Cl     OCHMeCCH           SO.sub.2 Me                                                                            H                                            Cl     OCMe.sub.2 CCH     SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CCMe     SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 F                                                                              SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            Cl     OCHMeCH.sub.2 Cl   SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                    SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                            H                                            Cl     Y8                 SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CClCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CClCHCl  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub. 2 CH.sub.2 NO.sub.2                                                                      SO.sub.2 Me                                                                            H                                            Cl     OPh                SO.sub.2 Me                                                                            H                                            Cl     OPhMe-2            SO.sub.2 Me                                                                            H                                            Cl     OPhCl-4            SO.sub.2 Me                                                                            H                                            Cl     OPhNO.sub.2 -4     SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2Y4                                                                              SO.sub.2 Me                                                                            H                                            Cl     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OPr-i                                                       SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 Ph       SO.sub.2 Me                                                                            H                                            Cl     OCHMePh            SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 Ph                                                                             SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 Ph-4-OMe SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                            H                                            Cl     Y9                 SO.sub.2 Me                                                                            H                                            Cl     Y10                SO.sub.2 Me                                                                            H                                            Cl     Y11                SO.sub.2 Me                                                                            H                                            Cl     Y12                SO.sub.2 Me                                                                            H                                            Cl     Y13                SO.sub.2 Me                                                                            H                                            Cl     Y14                SO.sub.2 Me                                                                            H                                            Cl     Y15                SO.sub.2 Me                                                                            H                                            Cl     Y16                SO.sub.2 Me                                                                            H                                            Cl     Y17                SO.sub.2 Me                                                                            H                                            Cl     Y18                SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 NMe.sub.2                                                                      SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                            H                                            Cl     Y19                SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 COOMe    SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 COOEt    SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 COOY4    SO.sub.2 Me                                                                            H                                            Cl     OCHMeCOOMe         SO.sub.2 Me                                                                            H                                            Cl     OCHMeCOOEt         SO.sub.2 Me                                                                            H                                            Cl     OCHMeCOOPr-i       SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 SMe      SO.sub. 2 Me                                                                           H                                            Cl     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            H                                            Cl     OCOOMe             SO.sub.2 Me                                                                            H                                            Cl     OCOOPr-i           SO.sub.2 Me                                                                            H                                            Cl     OCONH.sub.2        SO.sub.2 Me                                                                            H                                            Cl     OCONHMe            SO.sub.2 Me                                                                            H                                            Cl     OCONMe.sub.2       SO.sub.2 Me                                                                            H                                            Cl     OP(O)(OMe).sub.2   SO.sub.2 Me                                                                            H                                            Cl     Y20                SO.sub.2 Me                                                                            H                                            Cl     SCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                            H                                            Cl     SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Cl     SCH.sub.2 C CH     SO.sub.2 Me                                                                            H                                            Cl     SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            Cl     SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            Cl     Y21                SO.sub.2 Me                                                                            H                                            Cl     SPh                SO.sub.2 Me                                                                            H                                            Cl     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            H                                            Cl     SCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            H                                            Cl     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            Cl     Y22                SO.sub.2 Me                                                                            H                                            Cl     S(O)CH.sub.2 CHCH.sub.2                                                                           SO.sub.2 Me                                                                            H                                            Cl     S(O)CH.sub.2 CHCMe.sub.2                                                                          SO.sub.2 Me                                                                            H                                            Cl     S(O)CH.sub.2 CCH   SO.sub.2 Me                                                                            H                                            Cl     S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                            H                                            Cl     Y23                SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 CHCMe.sub.2                                                                     SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 CCH                                                                             SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                            H                                            Cl     Y24                SO.sub.2 Me                                                                            H                                            Cl     Y25                SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 Ph        SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 CH.sub.2 OEt                                                                    SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 SOMe                                                                           SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            Cl     OCH.sub.2 CH.sub.2 OEt                                                                            Cl      H                                            Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl      H                                            Cl     OCHMeCH.sub.2 OMe  Cl      H                                            Cl     OCH.sub.2 COOMe    Cl      H                                            Cl     OCH.sub.2 CH.sub.2 SMe                                                                            Cl      H                                            Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      H                                            Cl     SCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      H                                            Cl     OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 SOMe                                                                           Cl      CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 Ph                                  Cl     SCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 Ph                                  Cl     SCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                Cl     SCH.sub.2 CH.sub.2 OEt                                                                            Cl      CH.sub.2 COPh                                Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 COPh                                OMe    Y1                 SO.sub.2 Me                                                                            H                                            OMe    Y2                 SO.sub.2 Me                                                                            H                                            OMe    Y3                 SO.sub.2 Me                                                                            H                                            OMe    Y4                 SO.sub.2 Me                                                                            H                                            OMe    Y5                 SO.sub.2 Me                                                                            H                                            OMe    Y6                 SO.sub.2 Me                                                                            H                                            OMe    Y7                 SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                            H                                            OMe    OCHMeCHCH.sub.2    SO.sub.2 Me                                                                            H                                            OMe    OCMe.sub.2 CHCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CMeCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CHCHMe   SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 CHCH.sub.2                                                                     SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CCH      SO.sub.2 Me                                                                            H                                            OMe    OCHMeC CH          SO.sub.2 Me                                                                            H                                            OMe    OCMe.sub.2 CCH     SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CCMe     SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 F                                                                              SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            OMe    OCHMeCH.sub.2 Cl   SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                    SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                            H                                            OMe    Y8                 SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CClCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CClCHCl  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 NO.sub.2                                                                       SO.sub.2 Me                                                                            H                                            OMe    OPh                SO.sub.2 Me                                                                            H                                            OMe    OPhMe-2            SO.sub.2 Me                                                                            H                                            OMe    OPhCl-4            SO.sub.2 Me                                                                            H                                            OMe    OPhNO.sub.2 -4     SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2Y4                                                                              SO.sub.2 Me                                                                            H                                            OMe    OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OPr-i                                                       SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 Ph       SO.sub.2 Me                                                                            H                                            OMe    OCHMePh            SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 Ph                                                                             SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 Ph-4-OMe SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                            H                                            OMe    Y9                 SO.sub.2 Me                                                                            H                                            OMe    Y10                SO.sub.2 Me                                                                            H                                            OMe    Y11                SO.sub.2 Me                                                                            H                                            OMe    Y12                SO.sub.2 Me                                                                            H                                            OMe    Y13                SO.sub.2 Me                                                                            H                                            OMe    Y14                SO.sub.2 Me                                                                            H                                            OMe    Y15                SO.sub.2 Me                                                                            H                                            OMe    Y16                SO.sub.2 Me                                                                            H                                            OMe    Y17                SO.sub.2 Me                                                                            H                                            OMe    Y18                SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub. 2 Me                                                                           H                                            OMe    OCH.sub.2 CH.sub.2 NMe.sub.2                                                                      SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                            H                                            OMe    Y19                SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 COOMe    SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 COOEt    SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 COOY4    SO.sub.2 Me                                                                            H                                            OMe    OCHMeCOOMe         SO.sub.2 Me                                                                            H                                            OMe    OCHMeCOOEt         SO.sub.2 Me                                                                            H                                            OMe    OCHMeCOOPr-i       SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 SMe      SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            H                                            OMe    OCOOMe             SO.sub.2 Me                                                                            H                                            OMe    OCOOPr-i           SO.sub.2 Me                                                                            H                                            OMe    OCONH.sub.2        SO.sub.2 Me                                                                            H                                            OMe    OCONHMe            SO.sub.2 Me                                                                            H                                            OMe    OCONMe.sub.2       SO.sub.2 Me                                                                            H                                            OMe    OP(O)(OMe).sub.2   SO.sub.2 Me                                                                            H                                            OMe    Y20                SO.sub.2 Me                                                                            H                                            OMe    SCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                            H                                            OMe    SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            OMe    SCH.sub.2 CCH      SO.sub.2 Me                                                                            H                                            OMe    SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            OMe    SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            OMe    Y21                SO.sub.2 Me                                                                            H                                            OMe    SPh                SO.sub.2 Me                                                                            H                                            OMe    SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            H                                            OMe    SCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            H                                            OMe    SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            OMe    Y22                SO.sub.2 Me                                                                            H                                            OMe    S(O)CH.sub.2 CHCH.sub.2                                                                           SO.sub.2 Me                                                                            H                                            OMe    S(O)CH.sub.2 CHCMe.sub.2                                                                          SO.sub.2 Me                                                                            H                                            OMe    S(O)CH.sub.2 CCH   SO.sub.2 Me                                                                            H                                            OMe    S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                            H                                            OMe    Y23                SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CHCMe.sub.2                                                                     SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CCH                                                                             SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                            H                                            OMe    Y24                SO.sub.2 Me                                                                            H                                            OMe    Y25                SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 Ph        SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CH.sub.2 OEt                                                                    SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub. 2 Ph                                 OMe    OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 SOMe                                                                           SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            OMe    OCH.sub.2 CH.sub.2 OEt                                                                            Cl      H                                            OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl      H                                            OMe    OCHMeCH.sub.2 OMe  Cl      H                                            OMe    OCH.sub.2 COOMe    Cl      H                                            OMe    OCH.sub.2 CH.sub.2 SMe                                                                            Cl      H                                            OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      H                                            OMe    SCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      H                                            OMe    OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 SOMe                                                                           Cl      CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 Ph                                  OMe    SCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 COPh                                OMe    SCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                OMe    SCH.sub. 2 CH.sub.2 OEt                                                                           Cl      CH.sub.2 COPh                                OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 COPh                                CH.sub.2 OMe                                                                          Y1                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y2                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y3                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y4                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y5                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y6                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y7                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMeCHCH.sub.2    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCMe.sub.2 CHCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CMeCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CHCHMe   SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 CHCH.sub.2                                                                     SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CCH      SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMeCCH           SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCMe.sub.2 CCH     SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CCMe     SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 F                                                                              SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMeCH.sub.2 Cl   SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y8                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CClCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CClCHCl  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NO.sub.2                                                                       SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OPh                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OPhMe-2            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OPhCl-4            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OPhNO.sub.2 -4     SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 Y4                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OPr-i                                                       SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 Ph       SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMePh            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 Ph                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 Ph-4-OMe SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y9                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y10                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y11                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y12                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y13                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y14                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y15                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y16                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y17                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y18                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NMe.sub.2                                                                      SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y19                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 COOMe    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 COOEt    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 COOY4    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMeCOOMe         SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMeCOOEt         SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMeCOOPr-i       SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 SMe      SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCOOMe             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCOOPr-i           SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCONH.sub.2        SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCONHMe            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCONMe.sub.2       SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OP(O)(OMe).sub.2   SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y20                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CCH      SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y21                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SPh                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y22                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          S(O)CH.sub.2 CHCH.sub.2                                                                           SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          S(O)CH.sub.2 CHCMe.sub.2                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          S(O)CH.sub.2 CCH   SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y23                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CHCMe.sub.2                                                                     SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CCH                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y24                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 Ph        SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OEt                                                                    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SOMe                                                                           SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OEt                                                                            Cl      H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl      H                                            CH.sub.2 OMe                                                                          OCHMeCH.sub.2 OMe  Cl      H                                            CH.sub.2 OMe                                                                          OCH.sub.2 COOMe    Cl      H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            Cl      H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SOMe                                                                           Cl      CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 COPh                                CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OEt                                                                            Cl      CH.sub.2 COPh                                CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 COPh                                ______________________________________                                    

                  TABLE 5                                                          ______________________________________                                          ##STR36##                                                                     X      Y                  Z       Q                                            ______________________________________                                         Me     Y1                 SO.sub.2 Me                                                                            H                                            Me     Y2                 SO.sub.2 Me                                                                            H                                            Me     Y3                 SO.sub.2 Me                                                                            H                                            Me     Y4                 SO.sub.2 Me                                                                            H                                            Me     Y5                 SO.sub.2 Me                                                                            H                                            Me     Y6                 SO.sub.2 Me                                                                            H                                            Me     Y7                 SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                            H                                            Me     OCHMeCH CH.sub.2   SO.sub.2 Me                                                                            H                                            Me     OCMe.sub.2 CH CH.sub.2                                                                            SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CMe CH.sub.2                                                                            SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CHCHMe   SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 CH CH.sub.2                                                                    SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 C CH     SO.sub.2 Me                                                                            H                                            Me     OCHMeC CH          SO.sub.2 Me                                                                            H                                            Me     OCHMe.sub.2 CCH    SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CCMe     SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 F                                                                              SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            Me     OCHMeCH.sub.2 Cl   SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                    SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                            H                                            Me     Y8                 SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CCl CH.sub.2                                                                            SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CCl CHCl SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 NO.sub.2                                                                       SO.sub.2 Me                                                                            H                                            Me     OPh                SO.sub.2 Me                                                                            H                                            Me     OPhMe-2            SO.sub.2 Me                                                                            H                                            Me     OPhCl-4            SO.sub.2 Me                                                                            H                                            Me     OPhNO.sub.2 -4     SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2Y4                                                                              SO.sub.2 Me                                                                            H                                            Me     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OPr-i                                                       SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 Ph       SO.sub.2 Me                                                                            H                                            Me     OCHMePh            SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 Ph                                                                             SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                            H                                            Me     OCH.sub. 2 Ph-4-OMe                                                                               SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                            H                                            Me     Y9                 SO.sub.2 Me                                                                            H                                            Me     Y10                SO.sub.2 Me                                                                            H                                            Me     Y11                SO.sub.2 Me                                                                            H                                            Me     Y12                SO.sub.2 Me                                                                            H                                            Me     Y13                SO.sub.2 Me                                                                            H                                            Me     Y14                SO.sub.2 Me                                                                            H                                            Me     Y15                SO.sub.2 Me                                                                            H                                            Me     Y16                SO.sub.2 Me                                                                            H                                            Me     Y17                SO.sub.2 Me                                                                            H                                            Me     Y18                SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 NMe.sub.2                                                                      SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                            H                                            Me     Y19                SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 COOMe    SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 COOEt    SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 COOY4    SO.sub.2 Me                                                                            H                                            Me     OCHMeCOOMe         SO.sub.2 Me                                                                            H                                            Me     OCHMeCOOEt         SO.sub.2 Me                                                                            H                                            Me     OCHMeCOOPr-i       SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 SMe      SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            H                                            Me     OCOOMe             SO.sub.2 Me                                                                            H                                            Me     OCOOPr-i           SO.sub.2 Me                                                                            H                                            Me     OCONH.sub.2        SO.sub.2 Me                                                                            H                                            Me     OCONHMe            SO.sub.2 Me                                                                            H                                            Me     OCONMe.sub.2       SO.sub.2 Me                                                                            H                                            Me     OP(O)(OMe).sub.2   SO.sub.2 Me                                                                            H                                            Me     Y20                SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 C CH     SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            Me     Y21                SO.sub.2 Me                                                                            H                                            Me     SPh                SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            Me     Y22                SO.sub.2 Me                                                                            H                                            Me     S(O)CH.sub.2 CH CH.sub.2                                                                          SO.sub.2 Me                                                                            H                                            Me     S(O)CH.sub.2 CH CMe.sub.2                                                                         SO.sub.2 Me                                                                            H                                            Me     S(O)CH.sub.2 CCH   SO.sub.2 Me                                                                            H                                            Me     S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                            H                                            Me     Y23                SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 CHCMe.sub.2                                                                     SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 C CH                                                                            SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                            H                                            Me     Y24                SO.sub.2 Me                                                                            H                                            Me     Y25                SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 Ph        SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 CH.sub.2 OEt                                                                    SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 SOMe                                                                           SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            Me     OCH.sub.2 CH.sub.2 OEt                                                                            Cl      H                                            Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl      H                                            Me     OCHMeCH.sub.2 OMe  Cl      H                                            Me     OCH.sub.2 COOMe    Cl      H                                            Me     OCH.sub.2 CH.sub.2 SMe                                                                            Cl      H                                            Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      H                                            Me     SCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      H                                            Me     OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 SOMe                                                                           Cl      CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 Ph                                  Me     SCH.sub.2 SH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 COPh                                Me     SCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                Me     SCH.sub.2 CH.sub.2 OEt                                                                            Cl      CH.sub.2 COPh                                Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 COPh                                Cl     Y1                 SO.sub.2 Me                                                                            H                                            Cl     Y2                 SO.sub.2 Me                                                                            H                                            Cl     Y3                 SO.sub.2 Me                                                                            H                                            Cl     Y4                 SO.sub.2 Me                                                                            H                                            Cl     Y5                 SO.sub.2 Me                                                                            H                                            Cl     Y6                 SO.sub.2 Me                                                                            H                                            Cl     Y7                 SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                            H                                            Cl     OCHMeCH CH.sub.2   SO.sub.2 Me                                                                            H                                            Cl     OCMe.sub.2 CH CH.sub.2                                                                            SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CMe CH.sub.2                                                                            SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CHCHMe   SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 CH CH.sub.2                                                                    SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 C CH     SO.sub.2 Me                                                                            H                                            Cl     OCHMeCCH           SO.sub.2 Me                                                                            H                                            Cl     OCHMe.sub.2 CCH    SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CCMe     SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 F                                                                              SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            Cl     OCHMeCH.sub.2 Cl   SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                    SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                            H                                            Cl     Y8                 SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CCl CH.sub.2                                                                            SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CCl CHCl SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 NO.sub.2                                                                       SO.sub.2 Me                                                                            H                                            Cl     OPh                SO.sub.2 Me                                                                            H                                            Cl     OPhMe-2            SO.sub.2 Me                                                                            H                                            Cl     OPhCl-4            SO.sub.2 Me                                                                            H                                            Cl     OPhNO.sub.2 -4     SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2Y4                                                                              SO.sub.2 Me                                                                            H                                            Cl     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OPr-i                                                       SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 Ph       SO.sub.2 Me                                                                            H                                            Cl     OCHMePh            SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 Ph                                                                             SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 Ph-4-OMe SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                            H                                            Cl     Y9                 SO.sub.2 Me                                                                            H                                            Cl     Y10                SO.sub.2 Me                                                                            H                                            Cl     Y11                SO.sub.2 Me                                                                            H                                            Cl     Y12                SO.sub.2 Me                                                                            H                                            Cl     Y13                SO.sub.2 Me                                                                            H                                            Cl     Y14                SO.sub.2 Me                                                                            H                                            Cl     Y15                SO.sub.2 Me                                                                            H                                            Cl     Y16                SO.sub.2 Me                                                                            H                                            Cl     Y17                SO.sub.2 Me                                                                            H                                            Cl     Y18                SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 NMe.sub.2                                                                      SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                            H                                            Cl     Y19                SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 COOMe    SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 COOEt    SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 COOY4    SO.sub.2 Me                                                                            H                                            Cl     OCHMeCOOMe         SO.sub.2 Me                                                                            H                                            Cl     OCHMeCOOEt         SO.sub.2 Me                                                                            H                                            Cl     OCHMeCOOPr-i       SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 SMe      SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 CO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            H                                            Cl     OCOOMe             SO.sub.2 Me                                                                            H                                            Cl     OCOOPr-i           SO.sub.2 Me                                                                            H                                            Cl     OCONH.sub.2        SO.sub.2 Me                                                                            H                                            Cl     OCONHMe            SO.sub.2 Me                                                                            H                                            Cl     OCONMe.sub.2       SO.sub.2 Me                                                                            H                                            Cl     OP(O)(OMe).sub.2   SO.sub.2 Me                                                                            H                                            Cl     Y20                SO.sub.2 Me                                                                            H                                            Cl     SCH.sub.2 CHCH.sub.2                                                                              SO.sub. 2 Me                                                                           H                                            Cl     SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Cl     SCH.sub.2 C CH     SO.sub.2 Me                                                                            H                                            Cl     SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            Cl     SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            Cl     Y21                SO.sub.2 Me                                                                            H                                            Cl     SPh                SO.sub.2 Me                                                                            H                                            Cl     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            H                                            Cl     SCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            H                                            Cl     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            Cl     Y22                SO.sub.2 Me                                                                            H                                            Cl     S(O)CH.sub.2 CH CH.sub.2                                                                          SO.sub.2 Me                                                                            H                                            Cl     S(O)CH.sub.2 CH CMe.sub.2                                                                         SO.sub.2 Me                                                                            H                                            Cl     S(O)CH.sub.2 CCH   SO.sub.2 Me                                                                            H                                            Cl     S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                            H                                            Cl     Y23                SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 CHCMe.sub.2                                                                     SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 C CH                                                                            SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                            H                                            Cl     Y24                SO.sub.2 Me                                                                            H                                            Cl     Y25                SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 Ph        SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 CH.sub.2 OEt                                                                    SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 SOMe                                                                           SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Cl                                                                            CH.sub.2 COPh                                Cl     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            Cl     OCH.sub.2 CH.sub.2 OEt                                                                            Cl      H                                            Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl      H                                            Cl     OCHMeCH.sub.2 OMe  Cl      H                                            Cl     OCH.sub.2 COOMe    Cl      H                                            Cl     OCH.sub.2 CH.sub.2 SMe                                                                            Cl      H                                            Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      H                                            Cl     SCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      H                                            Cl     OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 SOMe                                                                           Cl      CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 Ph                                  Cl     SCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 COPh                                Cl     SCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                Cl     SCH.sub.2 CH.sub.2 OEt                                                                            Cl      CH.sub.2 COPh                                Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 COPh                                OMe    Y1                 SO.sub.2 Me                                                                            H                                            OMe    Y2                 SO.sub.2 Me                                                                            H                                            OMe    Y3                 SO.sub.2 Me                                                                            H                                            OMe    Y4                 SO.sub.2 Me                                                                            H                                            OMe    Y5                 SO.sub.2 Me                                                                            H                                            OMe    Y6                 SO.sub.2 Me                                                                            H                                            OMe    Y7                 SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                            H                                            OMe    OCHMeCH CH.sub.2   SO.sub.2 Me                                                                            H                                            OMe    OCMe.sub.2 CH CH.sub.2                                                                            SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CMe CH.sub.2                                                                            SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CHCHMe   SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 CH CH.sub.2                                                                    SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 C CH     SO.sub.2 Me                                                                            H                                            OMe    OCHMeCCH           SO.sub.2 Me                                                                            H                                            OMe    OCHMe.sub.2 CCH    SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CCMe     SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 F                                                                              SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            OMe    OCHMeCH.sub.2 Cl   SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                    SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                            H                                            OMe    Y8                 SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CCl CH.sub.2                                                                            SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CCl CHCl SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 NO.sub.2                                                                       SO.sub.2 Me                                                                            H                                            OMe    OPh                SO.sub.2 Me                                                                            H                                            OMe    OPhMe-2            SO.sub.2 Me                                                                            H                                            OMe    OPhCl-4            SO.sub.2 Me                                                                            H                                            OMe    OPhNO.sub.2 -4     SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2Y4                                                                              SO.sub.2 Me                                                                            H                                            OMe    OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OPr-i                                                       SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 Ph       SO.sub.2 Me                                                                            H                                            OMe    OCHMePh            SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 Ph                                                                             SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 Ph-4-OMe SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                            H                                            OMe    Y9                 SO.sub.2 Me                                                                            H                                            OMe    Y10                SO.sub.2 Me                                                                            H                                            OMe    Y11                SO.sub.2 Me                                                                            H                                            OMe    Y12                SO.sub.2 Me                                                                            H                                            OMe    Y13                SO.sub.2 Me                                                                            H                                            OMe    Y14                SO.sub.2 Me                                                                            H                                            OMe    Y15                SO.sub.2 Me                                                                            H                                            OMe    Y16                SO.sub.2 Me                                                                            H                                            OMe    Y17                SO.sub.2 Me                                                                            H                                            OMe    Y18                SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 NMe.sub.2                                                                      SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                            H                                            OMe    Y19                SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 COOMe    SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 COOEt    SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 COOY4    SO.sub.2 Me                                                                            H                                            OMe    OCHMeCOOMe         SO.sub.2 Me                                                                            H                                            OMe    OCHMeCOOEt         SO.sub.2 Me                                                                            H                                            OMe    OCHMeCOOPr-i       SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 SMe      SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            H                                            OMe    OCOOMe             SO.sub.2 Me                                                                            H                                            OMe    OCOOPr-i           SO.sub.2 Me                                                                            H                                            OMe    OCONH.sub.2        SO.sub.2 Me                                                                            H                                            OMe    OCONHMe            SO.sub.2 Me                                                                            H                                            OMe    OCONMe.sub.2       SO.sub.2 Me                                                                            H                                            OMe    OP(O)(OMe).sub.2   SO.sub.2 Me                                                                            H                                            OMe    Y20                SO.sub.2 Me                                                                            H                                            OMe    SCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                            H                                            OMe    SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            OMe    SCH.sub.2 CCH      SO.sub.2 Me                                                                            H                                            OMe    SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            OMe    SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            OMe    Y21                SO.sub.2 Me                                                                            H                                            OMe    SPh                SO.sub.2 Me                                                                            H                                            OMe    SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            H                                            OMe    SCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            H                                            OMe    SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            OMe    Y22                SO.sub.2 Me                                                                            H                                            OMe    S(O)CH.sub.2 CHCH.sub.2                                                                           SO.sub.2 Me                                                                            H                                            OMe    S(O)CH.sub.2 CHCMe.sub.2                                                                          SO.sub.2 Me                                                                            H                                            OMe    S(O)CH.sub.2 CCH   SO.sub.2 Me                                                                            H                                            OMe    S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                            H                                            OMe    Y23                SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CHCMe.sub.2                                                                     SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CCH                                                                             SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                            H                                            OMe    Y24                SO.sub.2 Me                                                                            H                                            OMe    Y25                SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 Ph        SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CH.sub.2 OEt                                                                    SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 SOMe                                                                           SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Cl                                                                            CH.sub.2 COPh                                OMe    SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            OMe    OCH.sub.2 CH.sub.2 OEt                                                                            Cl      H                                            OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl      H                                            OMe    OCHMeCH.sub.2 OMe  Cl      H                                            OMe    OCH.sub.2 COOMe    Cl      H                                            OMe    OCH.sub.2 CH.sub.2 SMe                                                                            Cl      H                                            OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      H                                            OMe    SCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      H                                            OMe    OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 SOMe                                                                           Cl      CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 Ph                                  OMe    SCH.sub.2 SH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 COPh                                OMe    SCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                OMe    SCH.sub.2 CH.sub.2 OEt                                                                            Cl      CH.sub.2 COPh                                OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 COPh                                CH.sub.2 OMe                                                                          Y1                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y2                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y3                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y4                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y5                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y6                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y7                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMeCH CH.sub.2   SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCMe.sub.2 CH CH.sub.2                                                                            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CMe CH.sub.2                                                                            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CHCHMe   SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 CH CH.sub.2                                                                    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub. 2 C CH    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMeCCH           SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMe.sub.2 CCH    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CCMe     SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 F                                                                              SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMeCH.sub.2 Cl   SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y8                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CCl CH.sub.2                                                                            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CCl CHCl SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NO.sub.2                                                                       SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OPh                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OPhMe-2            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OPhCl-4            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OPhNO.sub.2 -4     SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2Y4                                                                              SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OPr-i                                                       SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 Ph       SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMePh            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 Ph                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 Ph-4-OMe SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y9                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y10                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y11                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y12                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y13                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y14                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y15                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y16                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y17                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y18                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NMe.sub.2                                                                      SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y19                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 COOMe    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 COOEt    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 COOY4    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMeCOOMe         SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMeCOOEt         SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMeCOOPr-i       SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 SMe      SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 CO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCOOMe             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCOOPr-i           SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCONH.sub.2        SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCONHMe            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCONMe.sub.2       SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OP(O)(OMe).sub.2   SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y20                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub.2 C CH     SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y21                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SPh                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub. 2 CH.sub.2 OMe                                                                           SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y22                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          S(O)CH.sub.2 CH CH.sub.2                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          S(O)CH.sub.2 CH CMe.sub.2                                                                         SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          S(O)CH.sub.2 CCH   SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y23                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CHCMe.sub.2                                                                     SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 C CH                                                                            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y24                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 Ph        SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OEt                                                                    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SOMe                                                                           SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Cl                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub. 2 OPr-i                                                                 SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OEt                                                                            Cl      H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl      H                                            CH.sub.2 OMe                                                                          OCHMeCH.sub.2 OMe  Cl      H                                            CH.sub.2 OMe                                                                          OCH.sub.2 COOMe    Cl      H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            Cl      H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SOMe                                                                           Cl      CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 COPh                                CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OEt                                                                            Cl      CH.sub.2 COPh                                CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 COPh                                ______________________________________                                    

                  TABLE 6                                                          ______________________________________                                          ##STR37##                                                                     X      Y                  Z        Q                                           ______________________________________                                         Me     Y1                 SO.sub.2 Me                                                                             H                                           Me     Y2                 SO.sub.2 Me                                                                             H                                           Me     Y3                 SO.sub.2 Me                                                                             H                                           Me     Y4                 SO.sub.2 Me                                                                             H                                           Me     Y5                 SO.sub.2 Me                                                                             H                                           Me     Y6                 SO.sub.2 Me                                                                             H                                           Me     Y7                 SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                             H                                           Me     OCHMeCHCH.sub.2    SO.sub.2 Me                                                                             H                                           Me     OCMe.sub.2 CHCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CMeCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CHCHMe   SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 CHCH.sub.2                                                                     SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CCH      SO.sub.2 Me                                                                             H                                           Me     OCHMeC CH          SO.sub.2 Me                                                                             H                                           Me     OCMe.sub.2 CCH     SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CCMe     SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 F                                                                              SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           Me     OCHMeCH.sub.2 Cl   SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                    SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                             H                                           Me     Y8                 SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CClCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CClCHCl  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 NO.sub.2                                                                       SO.sub.2 Me                                                                             H                                           Me     OPh                SO.sub.2 Me                                                                             H                                           Me     OPhMe-2            SO.sub.2 Me                                                                             H                                           Me     OPhCl-4            SO.sub.2 Me                                                                             H                                           Me     OPhNO.sub.2 -4     SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub. 2 OEt                                                                           SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2Y4                                                                              SO.sub.2 Me                                                                             H                                           Me     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OPr-i                                                       SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 Ph       SO.sub.2 Me                                                                             H                                           Me     OCHMePh            SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 Ph                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 Ph-4-OMe SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                             H                                           Me     Y9                 SO.sub.2 Me                                                                             H                                           Me     Y10                SO.sub.2 Me                                                                             H                                           Me     Y11                SO.sub.2 Me                                                                             H                                           Me     Y12                SO.sub.2 Me                                                                             H                                           Me     Y13                SO.sub.2 Me                                                                             H                                           Me     Y14                SO.sub.2 Me                                                                             H                                           Me     Y15                SO.sub.2 Me                                                                             H                                           Me     Y16                SO.sub.2 Me                                                                             H                                           Me     Y17                SO.sub.2 Me                                                                             H                                           Me     Y18                SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 NMe.sub.2                                                                      SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                             H                                           Me     Y19                SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 COOMe    SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 COOEt    SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 COOY4    SO.sub.2 Me                                                                             H                                           Me     OCHMeCOOMe         SO.sub.2 Me                                                                             H                                           Me     OCHMeCOOEt         SO.sub.2 Me                                                                             H                                           Me     OCHMeCOOPr-i       SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 SMe      SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             H                                           Me     OCOOMe             SO.sub.2 Me                                                                             H                                           Me     OCOOPr-i           SO.sub.2 Me                                                                             H                                           Me     OCONH.sub.2        SO.sub.2 Me                                                                             H                                           Me     OCONHMe            SO.sub.2 Me                                                                             H                                           Me     OCONMe.sub.2       SO.sub.2 Me                                                                             H                                           Me     OP(O)(OMe).sub.2   SO.sub.2 Me                                                                             H                                           Me     Y20                SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CCH      SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           Me     Y21                SO.sub.2 Me                                                                             H                                           Me     SPh                SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           Me     Y22                SO.sub.2 Me                                                                             H                                           Me     S(O)CH.sub.2 CHCH.sub.2                                                                           SO.sub.2 Me                                                                             H                                           Me     S(O)CH.sub.2 CHCMe.sub.2                                                                          SO.sub.2 Me                                                                             H                                           Me     S(O)CH.sub.2 CCH   SO.sub.2 Me                                                                             H                                           Me     S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                             H                                           Me     Y23                SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CHCMe.sub.2                                                                     SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CCH                                                                             SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                             H                                           Me     Y24                SO.sub.2 Me                                                                             H                                           Me     Y25                SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 Ph        SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CH.sub.2 OEt                                                                    SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 SOMe                                                                           SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           Me     OCH.sub.2 CH.sub.2 OEt                                                                            Cl       H                                           Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl       H                                           Me     OCHMeCH.sub.2 OMe  Cl       H                                           Me     OCH.sub.2 COOMe    Cl       H                                           Me     OCH.sub.2 CH.sub.2 SMe                                                                            Cl       H                                           Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       H                                           Me     SCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       H                                           Me     OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 Me     OCH.sub. 2 CH.sub.2 SMe                                                                           Cl       CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 SOMe                                                                           Cl       CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 Ph                                 Me     SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 SMe                                                                            Cl       CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 COPh                               Me     SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               Me     SCH.sub.2 CH.sub.2 OEt                                                                            Cl       CH.sub.2 COPh                               Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 COPh                               Cl     Y1                 SO.sub.2 Me                                                                             H                                           Cl     Y2                 SO.sub.2 Me                                                                             H                                           Cl     Y3                 SO.sub.2 Me                                                                             H                                           Cl     Y4                 SO.sub.2 Me                                                                             H                                           Cl     Y5                 SO.sub.2 Me                                                                             H                                           Cl     Y6                 SO.sub.2 Me                                                                             H                                           Cl     Y7                 SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                             H                                           Cl     OCHMeCHCH.sub.2    SO.sub.2 Me                                                                             H                                           Cl     OCMe.sub.2 CHCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CMeCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH CHMe  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 CHCH.sub.2                                                                     SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CCH      SO.sub.2 Me                                                                             H                                           Cl     OCHMeCCH           SO.sub.2 Me                                                                             H                                           Cl     OCMe.sub.2 CCH     SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CCMe     SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 F                                                                              SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           Cl     OCHMeCH.sub.2 Cl   SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                    SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                             H                                           Cl     Y8                 SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CClCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CClCHCl  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 NO.sub.2                                                                       SO.sub.2 Me                                                                             H                                           Cl     OPh                SO.sub.2 Me                                                                             H                                           Cl     OPhMe-2            SO.sub.2 Me                                                                             H                                           Cl     OPhCl-4            SO.sub.2 Me                                                                             H                                           Cl     OPhNO.sub.2 -4     SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2Y4                                                                              SO.sub.2 Me                                                                             H                                           Cl     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OPr-i                                                       SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 Ph       SO.sub.2 Me                                                                             H                                           Cl     OCHMePh            SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 Ph                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 Ph-4-OMe SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                             H                                           Cl     Y9                 SO.sub.2 Me                                                                             H                                           Cl     Y10                SO.sub.2 Me                                                                             H                                           Cl     Y11                SO.sub.2 Me                                                                             H                                           Cl     Y12                SO.sub.2 Me                                                                             H                                           Cl     Y13                SO.sub.2 Me                                                                             H                                           Cl     Y14                SO.sub.2 Me                                                                             H                                           Cl     Y15                SO.sub.2 Me                                                                             H                                           Cl     Y16                SO.sub.2 Me                                                                             H                                           Cl     Y17                SO.sub.2 Me                                                                             H                                           Cl     Y18                SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 NMe.sub.2                                                                      SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                             H                                           Cl     Y19                SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 COOMe    SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 COOEt    SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 COOY4    SO.sub.2 Me                                                                             H                                           Cl     OCHMeCOOMe         SO.sub.2 Me                                                                             H                                           Cl     OCHMeCOOEt         SO.sub.2 Me                                                                             H                                           Cl     OCHMeCOOPr-i       SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 SMe      SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             H                                           Cl     OCOOMe             SO.sub.2 Me                                                                             H                                           Cl     OCOOPr-i           SO.sub.2 Me                                                                             H                                           Cl     OCONH.sub.2        SO.sub.2 Me                                                                             H                                           Cl     OCONHMe            SO.sub.2 Me                                                                             H                                           Cl     OCONMe.sub.2       SO.sub.2 Me                                                                             H                                           Cl     OP(O)(OMe).sub.2   SO.sub.2 Me                                                                             H                                           Cl     Y20                SO.sub.2 Me                                                                             H                                           Cl     SCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                             H                                           Cl     SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Cl     SCH.sub.2 C CH     SO.sub.2 Me                                                                             H                                           Cl     SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           Cl     SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           Cl     Y21                SO.sub.2 Me                                                                             H                                           Cl     SPh                SO.sub.2 Me                                                                             H                                           Cl     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           Cl     SCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             H                                           Cl     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           Cl     Y22                SO.sub.2 Me                                                                             H                                           Cl     S(O)CH.sub.2 CHCH.sub.2                                                                           SO.sub.2 Me                                                                             H                                           Cl     S(O)CH.sub.2 CHCMe.sub.2                                                                          SO.sub.2 Me                                                                             H                                           Cl     S(O)CH.sub.2 CCH   SO.sub.2 Me                                                                             H                                           Cl     S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                             H                                           Cl     Y23                SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 CHCMe.sub.2                                                                     SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 CCH                                                                             SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                             H                                           Cl     Y24                SO.sub.2 Me                                                                             H                                           Cl     Y25                SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 Ph        SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 CH.sub.2 OEt                                                                    SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub. 2 Ph                                Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 SOMe                                                                           SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           Cl     OCH.sub.2 CH.sub.2 OEt                                                                            Cl       H                                           Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl       H                                           Cl     OCHMeCH.sub.2 OMe  Cl       H                                           Cl     OCH.sub.2 COOMe    Cl       H                                           Cl     OCH.sub.2 CH.sub.2 SMe                                                                            Cl       H                                           Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       H                                           Cl     SCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       H                                           Cl     OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 SMe                                                                            Cl       CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 SOMe                                                                           Cl       CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 Ph                                 Cl     SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 SMe                                                                            Cl       CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 COPh                               Cl     SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               Cl     SCH.sub.2 CH.sub.2 OEt                                                                            Cl       CH.sub.2 COPh                               Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 COPh                               OMe    Y1                 SO.sub.2 Me                                                                             H                                           OMe    Y2                 SO.sub.2 Me                                                                             H                                           OMe    Y3                 SO.sub.2 Me                                                                             H                                           OMe    Y4                 SO.sub.2 Me                                                                             H                                           OMe    Y5                 SO.sub.2 Me                                                                             H                                           OMe    Y6                 SO.sub.2 Me                                                                             H                                           OMe    Y7                 SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                             H                                           OMe    OCHMeCHCH.sub.2    SO.sub.2 Me                                                                             H                                           OMe    OCMe.sub.2 CHCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CMeCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CHCHMe   SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 CHCH.sub.2                                                                     SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CCH      SO.sub.2 Me                                                                             H                                           OMe    OCHMeCCH           SO.sub.2 Me                                                                             H                                           OMe    OCMe.sub.2 CCH     SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CCMe     SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 F                                                                              SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           OMe    OCHMeCH.sub. 2 Cl  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                    SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                             H                                           OMe    Y8                 SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CClCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CClCHCl  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 NO.sub.2                                                                       SO.sub.2 Me                                                                             H                                           OMe    OPh                SO.sub.2 Me                                                                             H                                           OMe    OPhMe-2            SO.sub.2 Me                                                                             H                                           OMe    OPhCl-4            SO.sub.2 Me                                                                             H                                           OMe    OPhNO.sub.2 -4     SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2Y4                                                                              SO.sub.2 Me                                                                             H                                           OMe    OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OPr-i                                                       SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 Ph       SO.sub.2 Me                                                                             H                                           OMe    OCHMePh            SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 Ph                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 Ph-4-OMe SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                             H                                           OMe    Y9                 SO.sub.2 Me                                                                             H                                           OMe    Y10                SO.sub.2 Me                                                                             H                                           OMe    Y11                SO.sub.2 Me                                                                             H                                           OMe    Y12                SO.sub.2 Me                                                                             H                                           OMe    Y13                SO.sub.2 Me                                                                             H                                           OMe    Y14                SO.sub.2 Me                                                                             H                                           OMe    Y15                SO.sub.2 Me                                                                             H                                           OMe    Y16                SO.sub.2 Me                                                                             H                                           OMe    Y17                SO.sub.2 Me                                                                             H                                           OMe    Y18                SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 NMe.sub.2                                                                      SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                             H                                           OMe    Y19                SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 COOMe    SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 COOEt    SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 COOY4    SO.sub.2 Me                                                                             H                                           OMe    OCHMeCOOMe         SO.sub.2 Me                                                                             H                                           OMe    OCHMeCOOEt         SO.sub.2 Me                                                                             H                                           OMe    OCHMeCOOPr-i       SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 SMe      SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             H                                           OMe    OCOOMe             SO.sub.2 Me                                                                             H                                           OMe    OCOOPr-i           SO.sub.2 Me                                                                             H                                           OMe    OCONH.sub.2        SO.sub. 2 Me                                                                            H                                           OMe    OCONHMe            SO.sub.2 Me                                                                             H                                           OMe    OCONMe.sub.2       SO.sub.2 Me                                                                             H                                           OMe    OP(O)(OMe).sub.2   SO.sub.2 Me                                                                             H                                           OMe    Y20                SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CCH      SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           OMe    Y21                SO.sub.2 Me                                                                             H                                           OMe    SPh                SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           OMe    Y22                SO.sub.2 Me                                                                             H                                           OMe    S(O)CH.sub.2 CHCH.sub.2                                                                           SO.sub.2 Me                                                                             H                                           OMe    S(O)CH.sub.2 CHCMe.sub.2                                                                          SO.sub.2 Me                                                                             H                                           OMe    S(O)CH.sub.2 CCH   SO.sub.2 Me                                                                             H                                           OMe    S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                             H                                           OMe    Y23                SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                             H                                           OMe    SO.sub. 2 CH.sub.2 CHCMe.sub.2                                                                    SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 CH.sub.2 CCH                                                                             SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                             H                                           OMe    Y24                SO.sub.2 Me                                                                             H                                           OMe    Y25                SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 Ph        SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 CH.sub.2 CH.sub.2 OEt                                                                    SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub. 2 Me                                                                            CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 SOMe                                                                           SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    SO.sub.2 CH.sub.2 CH.sub. 2 OMe                                                                   SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           OMe    OCH.sub.2 CH.sub.2 OEt                                                                            Cl       H                                           OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl       H                                           OMe    OCHMeCH.sub.2 OMe  Cl       H                                           OMe    OCH.sub.2 COOMe    Cl       H                                           OMe    OCH.sub.2 CH.sub.2 SMe                                                                            Cl       H                                           OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       H                                           OMe    SCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       H                                           OMe    OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 SMe                                                                            Cl       CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 SOMe                                                                           Cl       CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 Ph                                 OMe    SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 SMe                                                                            Cl       CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 COPh                               OMe    SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               OMe    SCH.sub.2 CH.sub.2 OEt                                                                            Cl       CH.sub.2 COPh                               OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 COPh                               CH.sub.2 OMe                                                                          Y1                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y2                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y3                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y4                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y5                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y6                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y7                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMeCHCH.sub.2    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCMe.sub.2 CHCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CMeCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CHCHMe   SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 CHCH.sub.2                                                                     SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CCH      SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMeCCH           SO.sub.2 Me                                                                             H                                           CH.sub. 2 OMe                                                                         OCMe.sub.2 CCH     SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CCMe     SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 F                                                                              SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMeCH.sub.2 Cl   SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y8                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CClCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CClCHCl  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NO.sub.2                                                                       SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OPh                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OPhMe-2            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OPhCl-4            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OPhNO.sub.2 -4     SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2Y4                                                                              SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OPr-i                                                       SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 Ph       SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMePh            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 Ph                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 Ph-4-OMe SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y9                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y10                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y11                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y12                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y13                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y14                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y15                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y16                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y17                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y18                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NMe.sub.2                                                                      SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y19                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 COOMe    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 COOEt    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 COOY4    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMeCOOMe         SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMeCOOEt         SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMeCOOPr-i       SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 SMe      SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCOOMe             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCOOPr-i           SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCONH.sub.2        SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCONHMe            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCONMe.sub.2       SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OP(O)(OMe).sub.2   SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y20                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CCH      SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y21                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SPh                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y22                SO.sub.2 Me                                                                             H                                           CH.sub. 2 OMe                                                                         S(O)CH.sub.2 CHCH.sub.2                                                                           SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          S(O)CH.sub.2 CHCMe.sub.2                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          S(O)CH.sub.2 CCH   SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y23                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CHCMe.sub.2                                                                     SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CCH                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y24                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 Ph        SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OEt                                                                    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             CH.sub. 2 Ph                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SOMe                                                                           SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OEt                                                                            Cl       H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl       H                                           CH.sub.2 OMe                                                                          OCHMeCH.sub.2 OMe  Cl       H                                           CH.sub.2 OMe                                                                          OCH.sub.2 COOMe    Cl       H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            Cl       H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            Cl       CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SOMe                                                                           Cl       CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            Cl       CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 COPh                               CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OEt                                                                            Cl       CH.sub.2 COPh                               CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 COPh                               ______________________________________                                    

                  TABLE 7                                                          ______________________________________                                          ##STR38##                                                                     X      Y                  Z        Q                                           ______________________________________                                         Me     Y1                 SO.sub.2 Me                                                                             H                                           Me     Y2                 SO.sub.2 Me                                                                             H                                           Me     Y3                 SO.sub.2 Me                                                                             H                                           Me     Y4                 SO.sub.2 Me                                                                             H                                           Me     Y5                 SO.sub.2 Me                                                                             H                                           Me     Y6                 SO.sub.2 Me                                                                             H                                           Me     Y7                 SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                             H                                           Me     OCHMeCHCH.sub.2    SO.sub.2 Me                                                                             H                                           Me     OCMe.sub.2 CHCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CMeCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CHCHMe   SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 CHCH.sub.2                                                                     SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CCH      SO.sub.2 Me                                                                             H                                           Me     OCHMeC CH          SO.sub.2 Me                                                                             H                                           Me     OCMe.sub.2 CCH     SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CCMe     SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 F                                                                              SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           Me     OCHMeCH.sub.2 Cl   SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                    SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                             H                                           Me     Y8                 SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CClCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CClCHCl  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 NO.sub.2                                                                       SO.sub.2 Me                                                                             H                                           Me     OPh                SO.sub.2 Me                                                                             H                                           Me     OPhMe-2            SO.sub.2 Me                                                                             H                                           Me     OPhCl-4            SO.sub.2 Me                                                                             H                                           Me     OPhNO.sub.2 -4     SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub. 2 Me                                                                            H                                           Me     OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 -Y4                                                                            SO.sub.2 Me                                                                             H                                           Me     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OPr-i                                                       SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 Ph       SO.sub.2 Me                                                                             H                                           Me     OCHMePh            SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 Ph                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 Ph-4-OMe SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                             H                                           Me     Y9                 SO.sub.2 Me                                                                             H                                           Me     Y10                SO.sub.2 Me                                                                             H                                           Me     Y11                SO.sub.2 Me                                                                             H                                           Me     Y12                SO.sub.2 Me                                                                             H                                           Me     Y13                SO.sub.2 Me                                                                             H                                           Me     Y14                SO.sub.2 Me                                                                             H                                           Me     Y15                SO.sub.2 Me                                                                             H                                           Me     Y16                SO.sub.2 Me                                                                             H                                           Me     Y17                SO.sub.2 Me                                                                             H                                           Me     Y18                SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 NMe.sub.2                                                                      SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                             H                                           Me     Y19                SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 COOMe    SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 COOEt    SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 COO-Y4   SO.sub.2 Me                                                                             H                                           Me     OCHMeCOOMe         SO.sub.2 Me                                                                             H                                           Me     OCHMeCOOEt         SO.sub.2 Me                                                                             H                                           Me     OCHMeCOOPr-i       SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 SMe      SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             H                                           Me     OCOOMe             SO.sub.2 Me                                                                             H                                           Me     OCOOPr-i           SO.sub.2 Me                                                                             H                                           Me     OCONHG.sub.2       SO.sub.2 Me                                                                             H                                           Me     OCONHMe            SO.sub.2 Me                                                                             H                                           Me     OCONMe.sub.2       SO.sub.2 Me                                                                             H                                           Me     OP(O)(OMe).sub.2   SO.sub.2 Me                                                                             H                                           Me     Y20                SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CCH      SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           Me     Y21                SO.sub.2 Me                                                                             H                                           Me     SPh                SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CH.sub. 2 OEt                                                                           SO.sub.2 Me                                                                             H                                           Me     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           Me     Y22                SO.sub.2 Me                                                                             H                                           Me     S(O)CH.sub.2 CHCH.sub.2                                                                           SO.sub.2 Me                                                                             H                                           Me     S(O)CH.sub.2 CHCMe.sub.2                                                                          SO.sub.2 Me                                                                             H                                           Me     S(O)CH.sub.2 CCH   SO.sub.2 Me                                                                             H                                           Me     S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                             H                                           Me     Y23                SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CHCMe.sub.2                                                                     SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CCH                                                                             SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                             H                                           Me     Y24                SO.sub.2 Me                                                                             H                                           Me     Y25                SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 Ph        SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CH.sub.2 OEt                                                                    SO.sub.2 Me                                                                             H                                           Me     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             H                                           Me     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 SOMe                                                                           SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           Me     OCH.sub.2 CH.sub.2 OEt                                                                            Cl       H                                           Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl       H                                           Me     OCHMeCH.sub.2 OMe  Cl       H                                           Me     OCH.sub.2 COOMe    Cl       H                                           Me     OCH.sub.2 CH.sub.2 SMe                                                                            Cl       H                                           Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       H                                           Me     SCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       H                                           Me     OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 SMe                                                                            Cl       CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 SOMe                                                                           Cl       CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 Ph                                 Me     SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 Ph                                 Me     OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 SMe                                                                            Cl       CH.sub.2 COPh                               Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 COPh                               Me     SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               Me     SCH.sub.2 CH.sub.2 OEt                                                                            Cl       CH.sub.2 COPh                               Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 COPh                               Cl     Y1                 SO.sub.2 Me                                                                             H                                           Cl     Y2                 SO.sub.2 Me                                                                             H                                           Cl     Y3                 SO.sub.2 Me                                                                             H                                           Cl     Y4                 SO.sub.2 Me                                                                             H                                           Cl     Y5                 SO.sub.2 Me                                                                             H                                           Cl     Y6                 SO.sub.2 Me                                                                             H                                           Cl     Y7                 SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                             H                                           Cl     OCHMeCHCH.sub.2    SO.sub.2 Me                                                                             H                                           Cl     OCMe.sub.2 CHCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CMeCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CHCHMe   SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 CHCH.sub.2                                                                     SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CCH      SO.sub.2 Me                                                                             H                                           Cl     OCHMeCCH           SO.sub.2 Me                                                                             H                                           Cl     OCMe.sub.2 CCH     SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CCMe     SOhd 2l Me                                                                              H                                           Cl     OCH.sub.2 CH.sub.2 F                                                                              SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           Cl     OCHMeCH.sub.2 Cl   SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                    SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                             H                                           Cl     Y8                 SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CClCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CClCHCl  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 NO.sub. 2                                                                      SO.sub.2 Me                                                                             H                                           Cl     OPh                SO.sub.2 Me                                                                             H                                           Cl     OPh-Me-2           SO.sub.2 Me                                                                             H                                           Cl     OPh-Cl-4           SO.sub.2 Me                                                                             H                                           Cl     OPh-NO.sub.2 -4    SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2-Y4                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OPr-i                                                       SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 Ph       SO.sub.2 Me                                                                             H                                           Cl     OCHMePh            SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 Ph                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 Ph-4-OMe SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                             H                                           Cl     Y9                 SO.sub.2 Me                                                                             H                                           Cl     Y10                SO.sub.2 Me                                                                             H                                           Cl     Y11                SO.sub.2 Me                                                                             H                                           Cl     Y12                SO.sub.2 Me                                                                             H                                           Cl     Y13                SO.sub.2 Me                                                                             H                                           Cl     Y14                SO.sub.2 Me                                                                             H                                           Cl     Y15                SO.sub.2 Me                                                                             H                                           Cl     Y16                SO.sub.2 Me                                                                             H                                           Cl     Y17                SO.sub.2 Me                                                                             H                                           Cl     Y18                SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 NMe.sub.2                                                                      SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                             H                                           Cl     Y19                SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 COOMe    SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 COOEt    SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 COO-Y4   SO.sub.2 Me                                                                             H                                           Cl     OCHMeCOOMe         SO.sub.2 Me                                                                             H                                           Cl     OCHMeCOOEt         SO.sub.2 Me                                                                             H                                           Cl     OCHMeCOOPr-i       SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 SMe      SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             H                                           Cl     OCOOMe             SO.sub.2 Me                                                                             H                                           Cl     OCOOPr-i           SO.sub.2 Me                                                                             H                                           Cl     OCONH.sub.2        SO.sub.2 Me                                                                             H                                           Cl     OCONHMe            SO.sub.2 Me                                                                             H                                           Cl     OCONMe.sub.2       SO.sub.2 Me                                                                             H                                           Cl     OP(O)(OMe).sub.2   SO.sub.2 Me                                                                             H                                           Cl     Y20                SO.sub.2 Me                                                                             H                                           Cl     SCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                             H                                           Cl     SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           Cl     SCH.sub.2 CCH      SO.sub. 2 Me                                                                            H                                           Cl     SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           Cl     SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           Cl     Y21                SO.sub.2 Me                                                                             H                                           Cl     SPh                SO.sub.2 Me                                                                             H                                           Cl     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           Cl     SCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             H                                           Cl     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           Cl     Y22                SO.sub.2 Me                                                                             H                                           Cl     S(O)CH.sub.2 CHCH.sub.2                                                                           SO.sub.2 Me                                                                             H                                           Cl     S(O)CH.sub.2 CHCMe.sub.2                                                                          SO.sub.2 Me                                                                             H                                           Cl     S(O)CH.sub.2 CCH   SO.sub.2 Me                                                                             H                                           Cl     S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                             H                                           Cl     Y23                SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 CHCMe.sub.2                                                                     SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 CCH                                                                             SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                             H                                           Cl     Y24                SO.sub.2 Me                                                                             H                                           Cl     Y25                SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 Ph        SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 cH.sub.2 OEt                                                                    SO.sub.2 Me                                                                             H                                           Cl     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             H                                           Cl     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.3 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 SOMe                                                                           SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           Cl     OCH.sub.2 CH.sub.2 OEt                                                                            Cl       H                                           Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl       H                                           Cl     OCHMeCH.sub.2 OMe  Cl       H                                           Cl     OCH.sub.2 COOMe    Cl       H                                           Cl     OCH.sub.2 CH.sub. 2 SMe                                                                           Cl       H                                           Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       H                                           Cl     SCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       H                                           Cl     OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 SMe                                                                            Cl       CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 SOMe                                                                           Cl       CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 Ph                                 Cl     SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 Ph                                 Cl     OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 SMe                                                                            Cl       CH.sub.2 COPh                               Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 COPh                               Cl     SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               Cl     SCH.sub.2 CH.sub.2 OEt                                                                            Cl       CH.sub.2 COPh                               Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 COPh                               OMe    Y1                 SO.sub.2 Me                                                                             H                                           OMe    Y2                 SO.sub.2 Me                                                                             H                                           OMe    Y3                 SO.sub.2 Me                                                                             H                                           OMe    Y4                 SO.sub.2 Me                                                                             H                                           OMe    Y5                 SO.sub.2 Me                                                                             H                                           OMe    Y6                 SO.sub.2 Me                                                                             H                                           OMe    Y7                 SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                             H                                           OMe    OCHMdCHCH.sub.2    SO.sub.2 Me                                                                             H                                           OMe    OCMe.sub.2 CHCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CMeCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CHCHMe   SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 CHCH.sub.2                                                                     SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CCH      SO.sub.2 Me                                                                             H                                           OMe    OCHMeCCH           SO.sub.2 Me                                                                             H                                           OMe    OCMe.sub.2 CCH     SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CCMe     SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 F                                                                              SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           OMe    OCHMeCH.sub.2 Cl   SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub. 2 CH.sub.2 Cl                                                                   SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                             H                                           OMe    Y8                 SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CClCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CClCHCl  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 NO.sub.2                                                                       SO.sub.2 Me                                                                             H                                           OMe    OPh                SO.sub.2 Me                                                                             H                                           OMe    OPhMe-2            SO.sub.2 Me                                                                             H                                           OMe    OPhCl-4            SO.sub.2 Me                                                                             H                                           OMe    OPhNO.sub.2 -4     SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 -Y4                                                                            SO.sub.2 Me                                                                             H                                           OMe    OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OPr-i                                                       SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 Ph       SO.sub.2 Me                                                                             H                                           OMe    OCHMePh            SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 Ph                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 Ph-4-OMe SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                             H                                           OMe    Y9                 SO.sub.2 Me                                                                             H                                           OMe    Y10                SO.sub.2 Me                                                                             H                                           OMe    Y11                SO.sub.2 Me                                                                             H                                           OMe    Y12                SO.sub.2 Me                                                                             H                                           OMe    Y13                SO.sub.2 Me                                                                             H                                           OMe    Y14                SO.sub.2 Me                                                                             H                                           OMe    Y15                SO.sub.2 Me                                                                             H                                           OMe    Y16                SO.sub.2 Me                                                                             H                                           OMe    Y17                SO.sub.2 Me                                                                             H                                           OMe    Y18                SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 NMe.sub.2                                                                      SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                             H                                           OMe    Y19                SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 COOMe    SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 COOEt    SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 COO-Y4   SO.sub.2 Me                                                                             H                                           OMe    OCHMeCOOMe         SO.sub.2 Me                                                                             H                                           OMe    OCHMeCOOEt         SO.sub.2 Me                                                                             H                                           OMe    OCHMeCOOPr-i       SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 SMe      SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             H                                           OMe    OCOOMe             SO.sub.2 Me                                                                             H                                           OMe    OCOOPr-i           SO.sub.2 Me                                                                             H                                           OMe    OCONH.sub.2        SO.sub.2 Me                                                                             H                                           OMe    OCONHMe            SO.sub.2 Me                                                                             H                                           OMe    OCONMe.sub. 2      SO.sub.2 Me                                                                             H                                           OMe    OP(O)(OMe).sub.2   SO.sub.2 Me                                                                             H                                           OMe    Y20                SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CCH      SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           OMe    Y21                SO.sub.2 Me                                                                             H                                           OMe    SPh                SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             H                                           OMe    SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           OMe    Y22                SO.sub.2 Me                                                                             H                                           OMe    S(O)CH.sub.2 CHCH.sub.2                                                                           SO.sub.2 Me                                                                             H                                           OMe    S(O)CH.sub.2 CHCMe.sub.2                                                                          SO.sub.2 Me                                                                             H                                           OMe    S(O)CH.sub.2 CCH   SO.sub.2 Me                                                                             H                                           OMe    S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                             H                                           OMe    Y23                SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 CH.sub.2 CHCMe.sub.2                                                                     SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 CH.sub.2 CCH                                                                             SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                             H                                           OMe    Y24                SO.sub.2 Me                                                                             H                                           OMe    Y25                SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 Ph        SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 CH.sub.2 CH.sub.2 OEt                                                                    SO.sub.2 Me                                                                             H                                           OMe    SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             H                                           OMe    OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub. 2 CH.sub.2 S(O)Pr-i                                                                      SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 SOMe                                                                           SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.1 Me                                                                             CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             CH.sub. 2 COPh                              OMe    SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           OMe    OCH.sub.2 CH.sub.2 OEt                                                                            Cl       H                                           OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl       H                                           OMe    OCHMeCH.sub.2 OMe  Cl       H                                           OMe    OCH.sub.2 COOMe    Cl       H                                           OMe    OCH.sub.2 CH.sub.2 SMe                                                                            Cl       H                                           OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       H                                           OMe    SCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       H                                           OMe    OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 SMe                                                                            Cl       CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 SOMe                                                                           Cl       CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 Ph                                 OMe    SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 Ph                                 OMe    OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 SMe                                                                            Cl       CH.sub.2 COPh                               OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 COPh                               OMe    SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               OMe    SCH.sub.2 CH.sub.2 OEt                                                                            Cl       CH.sub.2 COPh                               OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 COPh                               CH.sub.2 OMe                                                                          Y1                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y2                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y3                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y4                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y5                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y6                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y7                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMeCHCH.sub.2    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCMe.sub.2 CHCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CMeCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CHCHMe   SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 CHCH.sub.2                                                                     SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CCH      SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMeCCH           SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCMe.sub.2 C CH    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CCMe     SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 F                                                                              SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMeCH.sub.2 Cl   SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y8                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CClCH.sub.2                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CClCHCl  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NO.sub.2                                                                       SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OPh                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OPhMe-2            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OPhCl-4            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OPh N.sub.2 -4     SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 -Y4                                                                            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OPr-i                                                       SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 Ph       SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMePh            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 Ph                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 Ph-4-OMe SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y9                 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y10                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y11                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y12                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y13                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y14                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y15                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y16                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y17                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y18                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NMe.sub.2                                                                      SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y19                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 COOMe    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 COOEt    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 COO-Y4   SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMeCOOMe         SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMeCOOEt         SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCHMeCOOPr-i       SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 SMe      SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCOOMe             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCOOPr-i           SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCONH.sub.2        SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCONHMe            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCONMe.sub.2       SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OP(O)(OMe).sub.2   SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y20                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CCH      SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y21                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SPh                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y22                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          S(O)CH.sub.2 CH CH.sub.2                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          S(O)CH.sub.2 CHCMe.sub.2                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          S(O)CH.sub.2 CCH   SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y23                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CHCMe.sub.2                                                                     SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CCH                                                                             SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          Y24                SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 Ph        SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OEt                                                                    SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 Pr-i                                                                           SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SOMe                                                                           SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                             CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OEt                                                                            Cl       H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl       H                                           CH.sub.2 OMe                                                                          OCHMeCH.sub.2 OMe  Cl       H                                           CH.sub.2 OMe                                                                          OCH.sub.2 COOMe    Cl       H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            Cl       H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       H                                           CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            Cl       H                                           CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       H                                           CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            Cl       CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SOMe                                                                           Cl       CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 Ph                                 CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            Cl       CH.sub.2 COPh                               CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl       CH.sub.2 COPh                               CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            Cl       CH.sub.2 COPh                               CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OEt                                                                            Cl       CH.sub.2 COPh                               CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl       CH.sub.2 COPh                               ______________________________________                                    

                  TABLE 8                                                          ______________________________________                                          ##STR39##                                                                     X      Y                  Z       Q                                            ______________________________________                                         Me     Y1                 SO.sub.2 Me                                                                            H                                            Me     Y2                 SO.sub.2 Me                                                                            H                                            Me     Y3                 SO.sub.2 Me                                                                            H                                            Me     Y4                 SO.sub.2 Me                                                                            H                                            Me     Y5                 SO.sub.2 Me                                                                            H                                            Me     Y6                 SO.sub.2 Me                                                                            H                                            Me     Y7                 SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                            H                                            Me     OCHMeCHCH.sub.2    SO.sub.2 Me                                                                            H                                            Me     OCMe.sub.2 CHCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CMeCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CHCHMe   SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 CHCH.sub.2                                                                     SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CCH      SO.sub.2 Me                                                                            H                                            Me     OCHMeC CH          SO.sub.2 Me                                                                            H                                            Me     OCMe.sub.2 CCH     SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CCMe     SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 F                                                                              SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            Me     OCHMeCH.sub.2 Cl   SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                    SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                            H                                            Me     Y8                 SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CClCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CClCHCl  SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 NO.sub.2                                                                       SO.sub.2 Me                                                                            H                                            Me     OPh                SO.sub.2 Me                                                                            H                                            Me     OPhMe-2            SO.sub.2 Me                                                                            H                                            Me     OPhCl-4            SO.sub.2 Me                                                                            H                                            Me     OPhNO.sub.2 -4     SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 Y4                                                                             SO.sub.2 Me                                                                            H                                            Me     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OPr-i                                                       SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 Ph       SO.sub.2 Me                                                                            H                                            Me     OCHMePh            SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 Ph                                                                             SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 Ph-4-OMe SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                            H                                            Me     Y9                 SO.sub.2 Me                                                                            H                                            Me     Y10                SO.sub.2 Me                                                                            H                                            Me     Y11                SO.sub.2 Me                                                                            H                                            Me     Y12                SO.sub.2 Me                                                                            H                                            Me     Y13                SO.sub.2 Me                                                                            H                                            Me     Y14                SO.sub.2 Me                                                                            H                                            Me     Y15                SO.sub.2 Me                                                                            H                                            Me     Y16                SO.sub.2 Me                                                                            H                                            Me     Y17                SO.sub.2 Me                                                                            H                                            Me     Y18                SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 NMe.sub.2                                                                      SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                            H                                            Me     Y19                SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 COOMe    SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 COOEt    SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 COOY4    SO.sub.2 Me                                                                            H                                            Me     OCHMeCOOMe         SO.sub.2 Me                                                                            H                                            Me     OCHMeCOOEt         SO.sub.2 Me                                                                            H                                            Me     OCHMeCOOPr-i       SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 SMe      SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            H                                            Me     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            H                                            Me     OCOOMe             SO.sub.2 Me                                                                            H                                            Me     OCOOPr-i           SO.sub.2 Me                                                                            H                                            Me     OCONH.sub.2        SO.sub.2 Me                                                                            H                                            Me     OCONHMe            SO.sub.2 Me                                                                            H                                            Me     OCONMe.sub.2       SO.sub.2 Me                                                                            H                                            Me     OP(O)(OMe).sub.2   SO.sub.2 Me                                                                            H                                            Me     Y20                SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 CCH      SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            Me     Y21                SO.sub.2 Me                                                                            H                                            Me     SPh                SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 CH.sub. 2 OEt                                                                           SO.sub.2 Me                                                                            H                                            Me     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            Me     Y22                SO.sub.2 Me                                                                            H                                            Me     S(O)CH.sub.2 CHCH.sub.2                                                                           SO.sub.2 Me                                                                            H                                            Me     S(O)CH.sub.2 CHCMe.sub.2                                                                          SO.sub.2 Me                                                                            H                                            Me     S(O)CH.sub.2 CCH   SO.sub.2 Me                                                                            H                                            Me     S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                            H                                            Me     Y23                SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 CHCMe.sub.2                                                                     SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 CCH                                                                             SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                            H                                            Me     Y24                SO.sub.2 Me                                                                            H                                            Me     Y25                SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 Ph        SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 CH.sub.2 OEt                                                                    SO.sub.2 Me                                                                            H                                            Me     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            H                                            Me     OCH.sub. 2 CH.sub.2 OMe                                                                           SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub. 2 SMe                                                                           SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 SOMe                                                                           SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub. 2 SO.sub.2 Pr-i                                                                 SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            Me     OCH.sub.2 CH.sub.2 OEt                                                                            Cl      H                                            Me     OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl      H                                            Me     OCHMeCH.sub.2 OMe  Cl      H                                            Me     OCH.sub.2 COOMe    Cl      H                                            Me     OCH.sub.2 CH.sub.2 SMe                                                                            Cl      H                                            Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      H                                            Me     SCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      H                                            Me     OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 SOMe                                                                           Cl      CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 Ph                                  Me     SCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 Ph                                  Me     OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 COPh                                Me     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 COPh                                Me     SCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                Me     SCH.sub.2 CH.sub.2 OEt                                                                            Cl      CH.sub.2 COPh                                Me     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 COPh                                Cl     Y1                 SO.sub.2 Me                                                                            H                                            Cl     Y2                 SO.sub.2 Me                                                                            H                                            Cl     Y3                 SO.sub.2 Me                                                                            H                                            Cl     Y4                 SO.sub.2 Me                                                                            H                                            Cl     Y5                 SO.sub.2 Me                                                                            H                                            Cl     Y6                 SO.sub.2 Me                                                                            H                                            Cl     Y7                 SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                            H                                            Cl     OCHMeCHCH.sub.2    SO.sub.2 Me                                                                            H                                            Cl     OCMe.sub.2 CHCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CMeCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CHCHMe   SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 CHCH.sub.2                                                                     SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 C CH     SO.sub.2 Me                                                                            H                                            Cl     OCHMeCCH           SO.sub.2 Me                                                                            H                                            Cl     OCMe.sub.2 CCH     SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CCMe     SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 F                                                                              SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            Cl     OCHMeCH.sub.2 Cl   SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                    SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                            H                                            Cl     Y8                 SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CClCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CClCHCl  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 NO.sub.2                                                                       SO.sub.2 Me                                                                            H                                            Cl     OPh                SO.sub.2 Me                                                                            H                                            Cl     OPhMe-2            SO.sub.2 Me                                                                            H                                            Cl     OPhCl-4            SO.sub.2 Me                                                                            H                                            Cl     OPhNO.sub.2 -4     SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2Y4                                                                              SO.sub.2 Me                                                                            H                                            Cl     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OPr-i                                                       SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 Ph       SO.sub.2 Me                                                                            H                                            Cl     OCHMePh            SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 Ph                                                                             SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 Ph-4-OMe SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                            H                                            Cl     Y9                 SO.sub.2 Me                                                                            H                                            Cl     Y10                SO.sub.2 Me                                                                            H                                            Cl     Y11                SO.sub.2 Me                                                                            H                                            Cl     Y12                SO.sub.2 Me                                                                            H                                            Cl     Y13                SO.sub.2 Me                                                                            H                                            Cl     Y14                SO.sub.2 Me                                                                            H                                            Cl     Y15                SO.sub.2 Me                                                                            H                                            Cl     Y16                SO.sub.2 Me                                                                            H                                            Cl     Y17                SO.sub.2 Me                                                                            H                                            Cl     Y18                SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 NMe.sub.2                                                                      SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                            H                                            Cl     Y19                SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 COOMe    SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 COOEt    SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 COO-Y4   SO.sub.2 Me                                                                            H                                            Cl     OCHMeCOOMe         SO.sub.2 Me                                                                            H                                            Cl     OCHMeCOOEt         SO.sub.2 Me                                                                            H                                            Cl     OCHMeCOOPr-i       SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 SMe      SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            H                                            Cl     OCOOMe             SO.sub.2 Me                                                                            H                                            Cl     OCOOPr-i           SO.sub.2 Me                                                                            H                                            Cl     OCONH.sub.2        SO.sub.2 Me                                                                            H                                            Cl     OCONHMe            SO.sub.2 Me                                                                            H                                            Cl     OCONMe.sub.2       SO.sub.2 Me                                                                            H                                            Cl     OP(O)(OMe).sub.2   SO.sub.2 Me                                                                            H                                            Cl     Y20                SO.sub.2 Me                                                                            H                                            Cl     SCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                            H                                            Cl     SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            Cl     SCH.sub.2 C CH     SO.sub.2 Me                                                                            H                                            Cl     SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            Cl     SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            Cl     Y21                SO.sub.2 Me                                                                            H                                            Cl     SPh                SO.sub.2 Me                                                                            H                                            Cl     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            H                                            Cl     SCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            H                                            Cl     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            Cl     Y22                SO.sub.2 Me                                                                            H                                            Cl     S(O)CH.sub.2 CHCH.sub.2                                                                           SO.sub.2 Me                                                                            H                                            Cl     S(O)CH.sub.2 CHCMe.sub.2                                                                          SO.sub.2 Me                                                                            H                                            Cl     S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                            H                                            Cl     Y23                SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 CHCMe.sub.2                                                                     SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 CCH                                                                             SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                            H                                            Cl     Y24                SO.sub.2 Me                                                                            H                                            Cl     Y25                SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 Ph        SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 CH.sub.2 OEt                                                                    SO.sub.2 Me                                                                            H                                            Cl     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            H                                            Cl     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 SOMe                                                                           SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            Cl     OCH.sub.2 CH.sub.2 OEt                                                                            Cl      H                                            Cl     OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl      H                                            Cl     OCHMeCH.sub.2 OMe  Cl      H                                            Cl     OCH.sub.2 COOMe    Cl      H                                            Cl     OCH.sub.2 CH.sub.2 SMe                                                                            Cl      H                                            Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      H                                            Cl     SCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      H                                            Cl     OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 SOMe                                                                           Cl      CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 Ph                                  Cl     SCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 Ph                                  Cl     OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 COPh                                Cl     OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 COPh                                Cl     SCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                Cl     SCH.sub.2 CH.sub.2 OEt                                                                            Cl      CH.sub.2 COPh                                Cl     SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 COPh                                OMe    Y1                 SO.sub.2 Me                                                                            H                                            OMe    Y2                 SO.sub.2 Me                                                                            H                                            OMe    Y3                 SO.sub.2 Me                                                                            H                                            OMe    Y4                 SO.sub.2 Me                                                                            H                                            OMe    Y5                 SO.sub.2 Me                                                                            H                                            OMe    Y6                 SO.sub.2 Me                                                                            H                                            OMe    Y7                 SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                            H                                            OMe    OCHMeCHCH.sub.2    SO.sub. 2 Me                                                                           H                                            OMe    OCMe.sub.2 CHCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CMeCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CHCHMe   SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 CHCH.sub.2                                                                     SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CCH      SO.sub.2 Me                                                                            H                                            OMe    OCHMeCCH           SO.sub.2 Me                                                                            H                                            OMe    OCMe.sub.2 CCH     SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CCMe     SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 F                                                                              SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            OMe    OCHMeCH.sub.2 Cl   SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                    SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                            H                                            OMe    Y8                 SO.sub. 2 Me                                                                           H                                            OMe    OCH.sub.2 CClCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CClCHCl  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 NO.sub.2                                                                       SO.sub.2 Me                                                                            H                                            OMe    OPh                SO.sub.2 Me                                                                            H                                            OMe    OPhMe-2            SO.sub.2 Me                                                                            H                                            OMe    OPhCl-4            SO.sub.2 Me                                                                            H                                            OMe    OPhNO.sub.2 -4     SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2Y4                                                                              SO.sub.2 Me                                                                            H                                            OMe    OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub. 2 OPr-i                                                      SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 Ph       SO.sub.2 Me                                                                            H                                            OMe    OCHMePh            SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 Ph                                                                             SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 Ph-4-OMe SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                            H                                            OMe    Y9                 SO.sub.2 Me                                                                            H                                            OMe    Y10                SO.sub.2 Me                                                                            H                                            OMe    Y11                SO.sub.2 Me                                                                            H                                            OMe    Y12                SO.sub.2 Me                                                                            H                                            OMe    Y13                SO.sub.2 Me                                                                            H                                            OMe    Y14                SO.sub.2 Me                                                                            H                                            OMe    Y15                SO.sub.2 Me                                                                            H                                            OMe    Y16                SO.sub.2 Me                                                                            H                                            OMe    Y17                SO.sub.2 Me                                                                            H                                            OMe    Y18                SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 NMe.sub.2                                                                      SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                            H                                            OMe    Y19                SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 COOMe    SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 COOEt    SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 COOY4    SO.sub.2 Me                                                                            H                                            OMe    OCHMeCOOMe         SO.sub.2 Me                                                                            H                                            OMe    OCHMeCOOEt         SO.sub.2 Me                                                                            H                                            OMe    OCHMeCOOPr-i       SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 SMe      SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            H                                            OMe    OCOOMe             SO.sub.2 Me                                                                            H                                            OMe    OCOOPr-i           SO.sub.2 Me                                                                            H                                            OMe    OCONH.sub.2        SO.sub.2 Me                                                                            H                                            OMe    OCONHMe            SO.sub.2 Me                                                                            H                                            OMe    OCONME.sub.2       SO.sub.2 Me                                                                            H                                            OMe    OP(O)(OMe).sub.2   SO.sub.2 Me                                                                            H                                            OMe    Y20                SO.sub.2 Me                                                                            H                                            OMe    SCH.sub. 2 CHCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            OMe    SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            OMe    SCH.sub.2 CCH      SO.sub.2 Me                                                                            H                                            OMe    SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            OMe    SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            OMe    Y21                SO.sub.2 Me                                                                            H                                            OMe    SPh                SO.sub.2 Me                                                                            H                                            OMe    SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            H                                            OMe    SCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            H                                            OMe    SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            OMe    Y22                SO.sub.2 Me                                                                            H                                            OMe    S(O)CH.sub.2 CHCH.sub.2                                                                           SO.sub.2 Me                                                                            H                                            OMe    S(O)CH.sub.2 CHCMe.sub.2                                                                          SO.sub.2 Me                                                                            H                                            OMe    S(O)CH.sub.2 CCH   SO.sub.2 Me                                                                            H                                            OMe    S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                            H                                            OMe    Y23                SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CHCMe.sub.2                                                                     SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CCH                                                                             SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                            H                                            OMe    Y24                SO.sub.2 Me                                                                            H                                            OMe    Y25                SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 Ph        SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CH.sub.2 OEt                                                                    SO.sub.2 Me                                                                            H                                            OMe    SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            H                                            OMe    OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    SCH.sub. 2 CH.sub.2 OMe                                                                           SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 SOMe                                                                           SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            OMe    OCH.sub. 2 CH.sub.2 OEt                                                                           Cl      H                                            OMe    OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl      H                                            OMe    OCHMeCH.sub.2 OMe  Cl      H                                            OMe    OCH.sub.2 COOMe    Cl      H                                            OMe    OCH.sub.2 CH.sub.2 SMe                                                                            Cl      H                                            OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      H                                            OMe    SCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      H                                            OMe    OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 SOMe                                                                           Cl      CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 Ph                                  OMe    SCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 Ph                                  OMe    OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 COPh                                OMe    OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 COPh                                OMe    SCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                OMe    SCH.sub.2 CH.sub.2 OEt                                                                            Cl      CH.sub.2 COPh                                OMe    SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 COPh                                CH.sub.2 OMe                                                                          Y1                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y2                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y3                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y4                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y5                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y6                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y7                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMeCHCH.sub.2    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMe.sub.2 CHCH.sub.2                                                                            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CMeCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CHCHMe   SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 CHCH.sub.2                                                                     SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CCH      SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMeCCH           SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCMe.sub.2 CCH     SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CCMe     SO.sub. 2 Me                                                                           H                                            CH.sub.2 OMe                                                                          OCH.sub. 2 CH.sub.2 F                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CHF.sub.2                                                                               SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 Cl                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMeCH.sub.2 Cl   SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 CH.sub.2 Cl                                                                    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 Br                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y8                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CClCH.sub.2                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CClCHCl  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NO.sub.2                                                                       SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OPh                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OPhMe-2            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OPhCl-4            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OPhNO.sub.2 -4     SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-n                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-n                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-i                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-s                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OBu-t                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2Y4                                                                              SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CHMeOMe  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPh                                                                            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OMe                                                         SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OPr-i                                                       SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OCHMeCH.sub.2 OMe                                                              SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OH                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 Ph       SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMePh            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub. 2 Ph                                                                            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 Ph-2-Cl  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 Ph-3-Me  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 Ph-4-OMe SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 Ph-4-NO.sub.2                                                                           SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y9                 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y10                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y11                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y12                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y13                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y14                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y15                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y16                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y17                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y18                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NH.sub.2                                                                       SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NHMe                                                                           SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NHPr-i                                                                         SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NMe.sub.2                                                                      SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 NEt.sub.2                                                                      SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y19                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 COOMe    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 COOEt    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 COOPr-i  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 COOBu-i  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 COOBu-t  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 COOY4    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMeCOOMe         SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMeCOOEt         SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCHMeCOOPr-i       SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 CN                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 SMe      SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCOOMe             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCOOPr-i           SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCONH.sub.2        SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCONHME            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCONMe.sub.2       SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OP(O)(OMe).sub.2   SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y20                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CHCH.sub.2                                                                              SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CHCMe.sub.2                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CCH      SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CF.sub.3 SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CCl.sub.3                                                                               SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y21                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SPh                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y22                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          S(O)CH.sub.2 CHCH.sub.2                                                                           SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          S(O)CH.sub.2 CHCMe.sub.2                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          S(O)CH.sub.2 C CH  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          S(O)CH.sub.2 CH.sub.2 Cl                                                                          SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y23                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CHCH.sub.2                                                                      SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CHCMe.sub.2                                                                     SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CCH                                                                             SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CF.sub.3                                                                        SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                     SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          Y24                SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 Ph        SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OEt                                                                    SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OEt                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCHMeCH.sub.2 OMe  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Me                                                                         SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 S(O)Pr-i                                                                       SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SOMe                                                                           SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Pr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OPr-i                                                                          SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OPr-i                                                                  SO.sub.2 Me                                                                            CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OEt                                                                            Cl      H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OPr-i                                                                          Cl      H                                            CH.sub.2 OMe                                                                          OCHMeCH.sub.2 OMe  Cl      H                                            CH.sub.2 OMe                                                                          OCH.sub.2 COOMe    Cl      H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            Cl      H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      H                                            CH.sub. 2 OMe                                                                         SCH.sub.2 CH.sub.2 OMe                                                                            Cl      H                                            CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      H                                            CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SOMe                                                                           Cl      CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 Ph                                  CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SMe                                                                            Cl      CH.sub.2 COPh                                CH.sub.2 OMe                                                                          OCH.sub.2 CH.sub.2 SO.sub.2 Me                                                                    Cl      CH.sub.2 COPh                                CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OMe                                                                            Cl      CH.sub.2 COPh                                CH.sub.2 OMe                                                                          SCH.sub.2 CH.sub.2 OEt                                                                            Cl      CH.sub.2 COPh                                CH.sub.2 OMe                                                                          SO.sub.2 CH.sub.2 CH.sub.2 OMe                                                                    Cl      CH.sub.2 COPh                                ______________________________________                                    

When the compound of the present invention is to be used as an agricultural or horticultural herbicide, it is usually mixed with a suitable carrier, for instance, a solid carrier such as clay, talc, bentonite or diatomaceous earth, or a liquid carrier such as water, an alcohol (such as benzene, toluene or xylene), a chlorinated hydrocarbon, an ether, a ketone, an ester (such as ethyl acetate) or an acid amide (such as dimethylformamide). If desired, an emulsifier, a dispersing agent, a suspending agent, a penetrating agent, a spreader or a stabilizer may be added to prepare an optional formulation such as a liquid formulation, an emulsifiable concentrate, a wettable powder, a dust, a granule or a flowable.

Further, if desired, other herbicides, various insecticides, bacteriocides, plant regulating agents or synergism agents may be combined at the time of the preparation of the formulations or at the time of the application of the herbicides.

As other herbicides to be combined with the herbicide of the present invention, there may be mentioned, for instance, compounds disclosed in Farm Chemicals Handbook, the 73rd Edition (1987). Among them, there may be mentioned, for example, atrazine, cyanazine, alachlor, metolachlor, EPTC, 2,4-D, butylate, dicamba, bromoxynil, tridiphane, isoproturon, chlortoluron, triallate, difluphenican, diclofop methyl, diphenzoquat, imazamethabenz methyl, ioxynil, methabenzthazuron, fluroxypil, chlorsulfuron and N-[(4,6-di(difluoromethoxy)pyrimidin-2-yl)aminocarbonyl]-2-methoxycarbonylbenzenesulfonamide. N-[(4,6-dimethoxypyrimidin-2-yl)-aminocarbonyl]-3-chloro-4-methoxycarbonyl-1-methylpyrazole-5-sulfonamide or N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-bromo-4-methoxycarbonyl-1-methylpyrazole-5sulfonamide as disclosed in U.S. Pat. No. 4,668,277, or N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-dimethylaminocarbonylpyridine-2-sulfonamide as disclosed in Japanese Unexamined Patent Publication No. 223180/1987 may also be combined with the herbicide of the present invention.

The dose varies depending upon the application site, the season for application, the method for application, the type of the crop plant, etc. In general, however, the dose is usually within a range of from 0.001 to 10 kg per hectare as the amount of the active ingredient.

Now, Formulation Examples of the herbicides containing the compounds of the present inveniton as active ingredients, will be given. However, it should be understood that the present invention is by no means restricted to such specific Examples. In the following Formulation Examples, "parts" means "parts by weight".

FORMULATION EXAMPLE 1 Wettable powder

    ______________________________________                                         Compound No. 1 of the present invention                                                                  60 parts                                             Zeeklite PFP (tradename for a kaolin-type                                                                33 parts                                             clay, manufactured by Zeeklite Industries,                                     Co., Ltd.)                                                                     Sorpol 5039 (tradename for a mixture of a                                                                 5 parts                                             nonionic surfactant and an anionic                                             surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     Carplex (tradename for a coagulation-                                                                     2 parts                                             preventing agent composed of a mixture of a                                    surfactant and fine silica powder,                                             manufactured by Shionogi Pharmaceutical                                        Co., Ltd.)                                                                     ______________________________________                                    

The above ingredients are homogeneously pulverized and mixed to form a wettable powder.

FORMULATION EXAMPLE 2 Emulsifiable concentrate

    ______________________________________                                         Compound No. 1 of the present invention                                                                  1.5 parts                                            Xylene                    78.5 parts                                           N,N-dimethylformamide     15 parts                                             Sorpol 2680 (tradename for a mixture of a                                                                5 parts                                              nonionic surfactant and an anionic                                             surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     ______________________________________                                    

The above ingredients are homogeneously mixed to form an emulsifiable concentrate.

FORMULATION EXAMPLE 3 Flowable

    ______________________________________                                         Compound No. 1 of the present invention                                                                   40 parts                                            Agrizole B-710 (tradename for a nonionic                                                                  10 parts                                            surfactant, manufactured by Kao                                                Corporation)                                                                   Runox 1000C (tradename for an anionic                                                                     0.5 part                                            surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     1% Rodopol water (tradename for a thickner,                                                               20 parts                                            manufactured by Rhone-Poulenc)                                                 Water                      29.5 parts                                          ______________________________________                                    

The above ingredients are homogeneously mixed to form a flowable.

FORMULATION EXAMPLE 4 Liquid formulation

    ______________________________________                                         Sodium salt of Compound No 1 of the                                                                     30 parts                                              present invention                                                              Nippol (tradename for a nonionic                                                                        10 parts                                              surfactant, manufactured by Nissan                                             Chemical Industries Ltd.)                                                      Water                    60 parts                                              ______________________________________                                    

The above ingredients are homogeneously mixed to obtain a liquid formulation.

FORMULATION EXAMPLE 5 Liquid formulation

    ______________________________________                                         Potassium salt of Compound No. 1 of the                                                                  30 parts                                             present invention                                                              Nippol (tradename for a nonionic                                                                         10 parts                                             surfactant, manufactured by Nissan                                             Chemical Industries Ltd.)                                                      Water                     60 parts                                             ______________________________________                                    

The above ingredients are homogeneously mixed to obtain a liquid formulation.

FORMULATION EXAMPLE 6 Liquid formulation

    ______________________________________                                         Calcium salt of Compound No. 1 of the                                                                    30 parts                                             present invention                                                              Nippol (tradename for a nonionic                                                                         10 parts                                             surfactant, manufactured by Nissan                                             Chemical Industries Ltd.)                                                      Water                     60 parts                                             ______________________________________                                    

The above ingredients are homogeneously mixed to obtain a liquid formulation.

FORMULATION EXAMPLE 7 Liquid formulation

    ______________________________________                                         Isopropylamine salt of Compound No. 1 of the                                                              10 parts                                            present invention                                                              Sorpol W-150 (tradename for a nonionic                                                                    10 parts                                            surfactant, manufactured by Toho Chemical                                      Co., Ltd.)                                                                     Water                      80 parts                                            ______________________________________                                    

The above ingredients are homogeneously mixed to form a liquid formulation.

In their use, the above wettable powder, emulsifiable concentrates, flowables or liquid formulations are diluted with water from 50 to 1,000 times and applied so that the respective active ingredients will be from 0.001 to 5 kg per hectare.

The compounds of the present invention are applicable not only to agricultural and horticultural fields such as upland fields, paddy fields and orchards, but also to non-agricultural fields such as athletic fields, vacant fields and railway sides for the control of various weeds. The dose in their application varies depending upon the application site, the season for application, the type of crop plants, etc. However, it is usually within a range of from 0.001 to 5 kg per hectare.

Now, the herbicidal activities of the compounds of the present invention will be described with respect to specific Test Examples.

TEST EXAMPLE 1: Test on the herbicidal effects in soil treatment

A plastic box having a length of 15 cm, a width of 22 cm and a depth of 6 cm was filled with a sterilized diluvium soil, and seeds of Echinochloa crus-galli, Setaria viridis, Eleusine indica, Digitaria adscendens, Panicum dichotomiflorum, Abutilon theophrasti, Amaranthus lividus, Polygonum longisetum and Zea mays were sown, and tubers of Cyperus esculentus were further planted. The soil was covered thereon in the thickness of about 1.5 cm, and then a herbicide solution was applied onto the surface of the soil uniformly so that the active ingredient was distributed at a predetermined concentration. The herbicide solution was prepared by diluting the wettable powder, the emulsifiable concentrate, the liquid formulation or the flowable as described in the foregoing Formulation Examples with water and applied onto the entire soil surface by means of a small spray. Three weeks after the application of the herbicidal solution, the herbicidal effects against each weed were determined on the basis of the following standard ratings. The results thereby obtained are shown in Table 9. The Compound Nos. correspond to the Compound Nos. in Table 2.

Standard ratings

5: Growth control rate of more than 90% (almost completely withered)

4: Growth control rate of from 70 to 90%

3: Growth control rate of from 40 to 70%

2: Growth control rate of from 20 to 40%

1: Growth control rate of from 5 to 20%

0: Growth control rate of less than 5% (almost non-effective)

The above growth control rates were calculated by the following equation: ##EQU1## where T: Weight of the weed growth above the soil surface of the treated area

N: Weight of the weed growth above the soil surface of the non-treated area

TEST EXAMPLE 2: Test 1 on the herbicidal effects in foliage treatment

A plastic box having a length of 15 cm, a width of 22 cm and a depth of 6 cm was filled with a sterilized diluvium soil, and seeds of Echinochloa crus-galli, Setaria viridis, Eleusine indica, Digitaria adscendens, Panicum dichotomiflorum, Xanthium strumatirum, Abutilon theophrasti, Amaranthus lividus, Polygonum longisetum and Zea mays were spot-wisely sown, and tubers of Cyperus esculentus were further planted. Then, the soil was covered thereon in a thickness of about 1.5 cm. When the various weeds and crop plant grew to the 2 or 3 leaf stage, a herbicidal solution was uniformly sprayed on the foliages so that the active ingredient was applied in a predetermined concentration.

The herbicidal solution was prepared by diluting the wettable powder, the emulsifiable concentrate, the liquid formulation or the flowable as described in the above Formulation Examples with water and applied onto the entire surface of the foliages of the weeds and the crop plants by a small spray. Two weeks after the application of the herbicide solution, the herbicidal effects against each weed and Zea mays were determined on the basis of the standard ratings described in Test Example 1. The results are shown in Table 10. The Compound Nos. in Table 10 correspond to the Compound Nos. in Table 2.

TEST EXAMPLE 3 Test 2 on the herbicidal effects in foliage treatment

A plastic box having a length of 15 cm, a width of 22 cm and a depth of 6 cm was filled with a sterilized diluvium soil, and seeds of Veronica persica, Stellaria media, Galium spurium, Matricaria matricarioides, Polygonum persicaria, Lamium purpureum, Solanum nigrum and Triticum aestivum were spot-wisely sown. Then, the soil was covered thereon in a thickness of about 1.5 cm. When the various weeds and crop plant grew to the 2 or 3 leaf atage, a herbicidal solution was uniformly sprayed on the foliages so that the active ingredient was applied in a predetermined concentration.

The herbicidal solution was prepared by diluting the wettable powder, the emulsifiable concentrate, the liquid formulation or the flowable as described in the above Formulation Examples with water and applied onto the entire surface of the foliages of the weeds and Triticum aestivum by a small spray. Two weeks after the application of the herbicide solution, the herbicidal effects against each weed and Triticum aestivum were determined on the basis of the standard ratings described in Test Example 1 The results are shown in Table 11. The Compound Nos in Table 11 correspond to Compound Nos. in Table 2.

In Tables 9, 10 and 11, the following abbreviations are used.

Dose: Dose of active ingredient (g/are)

EC: Echinochloa crus-galli (barnyardgrass)

SE: Setaria viridis (green foxtail)

EL: Eleusine indica (goosegrass)

DI: Digitaria adscendens (large crabgrass)

PA: Panicum dichotomiflorum (fall panicum)

AB: Abutilon theophrasti (velvet leaf)

AM: Amaranthus lividus (livid amaranth)

PO: Polygonum longisetum (persicaria blumei gross)

XA: Xanthium strumarium (cocklebur)

CY: Cyperus esculentus (yellow nutsedge)

ZE: Zea mays (corn)

VE: Veronica persia (birdseye speedweell)

ST: Stellaria media (chickweed)

GA: Galium spurium (catchweed)

MA: Matricaria matricarioides (pineappleweed)

PP: Polygonum persicaria (ladysthumb)

LA: Lamium purpureum (red deadnettle)

SO: Solanum nigrum (black nigthshade)

TR: Triticum aestivum (wheat)

                                      TABLE 9                                      __________________________________________________________________________     Compound                                                                             Dose                                                                     No.   g/are                                                                              EC SE                                                                               EL DI                                                                               PA AB AM PO CY ZE                                          __________________________________________________________________________      1    1   5  5 5  5 5  5  5  5  5  0                                                 2   5  5 5  5 5  5  5  5  5  0                                                 4   5  5 5  5 5  5  5  5  5  0                                            4    1   5  5 5  5 5  5  5  5  5  0                                                 2   5  5 5  5 5  5  5  5  5  0                                                 4   5  5 5  5 5  5  5  5  5  0                                            6    1   5  5 5  5 5  5  5  5  5  0                                                 2   5  5 5  5 5  5  5  5  5  0                                                 4   5  5 5  5 5  5  5  5  5  0                                            7    1   5  5 5  5 5  5  5  5  5  0                                                 2   5  5 5  5 5  5  5  5  5  0                                                 4   5  5 5  5 5  5  5  5  5  0                                           11    1   5  5 5  5 5  5  5  5  5  0                                                 2   5  5 5  5 5  5  5  5  5  0                                                 4   5  5 5  5 5  5  5  5  5  0                                           18    1   5  5 5  5 5  5  5  5  5  0                                                 2   5  5 5  5 5  5  5  5  5  0                                                 4   5  5 5  5 5  5  5  5  5  0                                           19    1   5  5 5  5 5  5  5  5  5  0                                                 2   5  5 5  5 5  5  5  5  5  0                                                 4   5  5 5  5 5  5  5  5  5  0                                           20    1   5  5 5  5 5  5  5  5  5  0                                                 2   5  5 5  5 5  5  5  5  5  0                                                 4   5  5 5  5 5  5  5  5  5  0                                           Compara-                                                                             4   3  1 3  3 1  4  5  5  0  0                                           tive  8   4  2 4  4 2  5  5  5  0  0                                           Compound                                                                             16  5  3 5  5 3  5  5  5  1  1                                           Compara-                                                                             4   5  5 5  5 5  1  1  1  2  0                                           tive  8   5  5 5  5 5  2  2  2  3  0                                           Compound                                                                             16  5  5 5  5 5  3  3  3  4  1                                           B                                                                              __________________________________________________________________________

                                      TABLE 10                                     __________________________________________________________________________     Compound                                                                             Dose                                                                     No.   g/are                                                                              EC SE                                                                               EL DI                                                                               PA AB AM PO XA CY ZE                                       __________________________________________________________________________      1    1   5  5 5  5 5  5  5  5  5  5  0                                              2   5  5 5  5 5  5  5  5  5  5  0                                              4   5  5 5  5 5  5  5  5  5  5  0                                         4    1   5  5 5  5 5  5  5  5  5  5  0                                              2   5  5 5  5 5  5  5  5  5  5  0                                              4   5  5 5  5 5  5  5  5  5  5  0                                         6    1   5  5 5  5 5  5  5  5  5  5  0                                              2   5  5 5  5 5  5  5  5  5  5  0                                              4   5  5 5  5 5  5  5  5  5  5  0                                         7    1   5  5 5  5 5  5  5  5  5  5  0                                              2   5  5 5  5 5  5  5  5  5  5  0                                              4   5  5 5  5 5  5  5  5  5  5  0                                        11    1   5  5 5  5 5  5  5  5  5  5  0                                              2   5  5 5  5 5  5  5  5  5  5  0                                              4   5  5 5  5 5  5  5  5  5  5  0                                        18    1   5  5 5  5 5  5  5  5  5  5  0                                              2   5  5 5  5 5  5  5  5  5  5  0                                              4   5  5 5  5 5  5  5  5  5  5  0                                        19    1   5  5 5  5 5  5  5  5  5  5  0                                              2   5  5 5  5 5  5  5  5  5  5  0                                              4   5  5 5  5 5  5  5  5  5  5  0                                        20    1   5  5 5  5 5  5  5  5  5  5  0                                              2   5  5 5  5 5  5  5  5  5  5  0                                              4   5  5 5  5 5  5  5  5  5  5  0                                        Compara-                                                                             4   3  1 2  3 0  3  5  5  4  0  0                                        tive  8   4  2 3  4 1  5  5  5  5  0  1                                        Compound                                                                             16  4  2 3  4 1  5  5  5  5  0  1                                        Compara-                                                                             4   4  3 3  4 3  0  2  2  0  1  0                                        tive  8   4  4 4  4 4  1  3  3  1  2  1                                        Compound                                                                             16  5  5 5  5 5  2  4  4  2  3  2                                        B                                                                              __________________________________________________________________________

                  TABLE 11                                                         ______________________________________                                         Com-                                                                           pound  Dose                                                                    No.    g/are   VE     ST  GA   MA   PP  LA   SO   TR                           ______________________________________                                          1     0.5     5      5   5    5    5   5    5    0                                   1       5      5   5    5    5   5    5    0                                   2       5      5   5    5    5   5    5    0                             7     0.5     5      5   5    5    5   5    5    0                                   1       5      5   5    5    5   5    5    0                                   2       5      5   5    5    5   5    5    0                            11     0.5     5      5   5    5    5   5    5    0                                   1       5      5   5    5    5   5    5    0                                   2       5      5   5    5    5   5    5    0                            18     0.5     5      5   5    5    5   5    5    0                                   1       5      5   5    5    5   5    5    0                                   2       5      5   5    5    5   5    5    0                            Compar-                                                                               1       4      4   3    2    4   2    4    0                            ative  2       5      5   4    4    5   4    5    1                            Com-                                                                           pound C                                                                        ______________________________________                                    

In Tables 9 and 10, the Comparative Compounds are as follows: ##STR40##

In Table 11, the Comparative Compound is as follows: 

We claim:
 1. A pyrazole derivative of the formula Iwherein A is a C₁ -C₄ alkyl group, a C₂ -C₄ alkenyl group or a C₂ -C₄ alkynyl group; B is a hydrogen atom, a C₁ -C₃ alkyl group, a halogen atom, a C₁ -C₃ haloalkyl group, a C₁ -C₃ alkoxy group, a C₁ -C₃ alkylthio group, a C₂ -C₄ alkoxyalkyl group, a C₂ -C₄ alkylthioalkyl group or a C₂ -C₄ alkoxycarbonyl group; X is a C₁ -C₆ alkyl group, a C₁ -C₆ alkoxy group, a halogen atom, a nitro group, a cyano group, a C₁ -C₆ haloalkyl group, a C₂ -C₆ alkoxyalkyl group, a C₂ -C₆ alkylcarbonyl group, a C₂ -C₆ alkoxycarbonyl group, an aminocarbonyl group substituted independently by hydrogen or by a C₁ -C₆ alkyl group, a C₁ -C₆ haloalkoxy group, a C₁ -C₆ alkylthio group or a C₂ -C₆ alkylthioalkyl group; Y is --OR¹ (wherein R¹ is a C₃ -C₈ cycloalkyl group, a C₄ -C₈ cycloalkylalkyl group, a C₃ -C₆ alkenyl group, a C₂ -C₆ alkynyl group, a C₁ -C₆ haloalkyl group, a C₃ -C₈ halocycloalkylalkyl group, a C₃ -C₆ haloalkenyl group, a C₂ -C₆ haloalkynyl group, a C₂ -C₆ nitroalkyl group or a phenyl group which may be substituted by a C₁ -C₃ alkyl group, a halogen atom, a nitro group or a C₁ -C₃ alkoxy group), --O--L--O--R¹ (wherein L is a C₁ -C₆ alkylene group which may be substituted by a C₁ -C₃ alkyl group, and R¹ is as defined above), --O--L--OH (wherein L is as defined above), --O--L--O--L--O--R² (wherein L is as defined above, and R² is a hydrogen atom, a C₁ -C₆ alkyl group or a phenyl group which may be substituted by a C₁ -C₃ alkyl group, a halogen atom, a nitro group or a C₁ -C₃ alkoxy group), --O--L--R³ (wherein L is as defined above, and R³ is a phenyl group which may be substituted by a C₁ -C₃ alkyl group, a halogen atom, a nitro group Or a C₁ -C₃ alkoxy group), --O--M (wherein M is a 3- to 6-membered alicyclic group containing not more than two sulfur or oxygen atoms and formed by a linkage of from 1 to 4 carbon atoms), --O--L--M (wherein L and M are as defined above), --O--L--NR⁴ R⁵ (wherein L is as defined above and each of R⁴ and R⁵ which may be the same or different is a hydrogen atom or a C₁ -C₆ alkyl group, or R⁴ and R⁵ form a 6-membered ring together with the adjacent nitrogen atom), --O--L--COOR⁴ (wherein L and R⁴ are as defined above), --O--CH═CH--COOR⁴ (wherein R⁴ is as defined above), --O--L--CN (wherein L is as defined above), --O--L--C(O)--R² (wherein L and R² are as defined above), --O--L--S(O)_(n) --R⁴ (wherein L and R⁴ are as defined above, and n is an integer of from 0 to 2), --O--COOR⁴ (wherein R⁴ are as defined above), --O--CONR⁴ R⁵ (wherein R.sup. 4 and R⁵ are as defined above), --OP(O)(OR⁴)₂ (wherein R⁴ is as defined above), --S(O)_(n) R¹ (wherein R¹ and n are as defined above), or --S(O)_(n) --L--O--R¹ (wherein L, R¹ and n are as defined above); Z is a halogen atom, a nitro group, a C₁ -C₃ alkoxy group, a trifluoromethyl group, a trifluoromethoxy group, a cyano group or --S(O)_(n) R⁶ (wherein n is as defined above, and R⁶ is a C₁ -C₃ alkyl group or a C₁ -C₃ haloalkyl group); V is a hydrogen atom, a halogen atom, a C₁ -C₄ alkyl group or a C₁ -C₄ alkoxy group; W is a hydrogen atom, a halogen atom, a C₁ -C₄ alkyl group, a C₁ -C₄ haloalkyl group, a C₁ -C₄ alkoxy group, a C₂ -C₆ alkoxyalkyl group, a C₂ -C₅ alkoxycarbonyl group, a C₁ -C₃ haloalkoxy group, a nitro group, a cyano group or --S(O)_(n) --R⁶ (wherein n and R⁶ are as defined above) and Q is a hydrogen atom, a C₁ -C₆ alkyl group which may be substituted by a halogen atom, a C₁ -C₆ alkenyl group which may be substituted by a halogen atom, a C₁ -C₆ alkynyl group which may be substituted by a halogen atom, a cyanomethyl group, --C(O)--R⁷ (wherein R⁷ is a phenyl group which may be substituted by the same or different substituents selected from the group consisting of a C₁ -C₆ alkyl group, a C₁ -C₆ alkenyl group, a C₁ -C₆ alkynyl group, a C₁ -C₆ haloalkyl group, a C₁ -C₆ haloalkenyl group, a C₁ -C₆ haloalkynyl group, a halogen atom, a nitro group and a trifluoromethyl group, a C₁ -C₆ alkyl group, a C₁ -C₆ alkoxy group, or a hydroxyl group), --S(O)₂ R⁷ (wherein R⁷ is as defined above), --P(O)(OR⁷)₂ (wherein R⁷ is as defined above), --L--C(O)--R⁷ (wherein L and R⁷ are as defined above), --L--C(O)--N(R⁸)(R⁹) (wherein L is as defined above, and each of R⁸ and R⁹ which may be the same or different is a hydrogen atom or a C₁ -C₆ alkyl group), --L--R¹⁰ (wherein L is as defined above, and R¹⁰ is a phenyl group which may be substituted by the same or different substituents selected from the group consisting of a halogen atom, a nitro group and a trifluoromethyl group, a C₁ -C₆ alkyl group, a C₁ -C₆ alkoxy group, or a hydroxyl group), --L--N(R⁸)(R⁹) (wherein L, R⁸ and R⁹ are as defined above), --L--OR¹¹ (wherein L is as defined above, and R¹¹ is a hydrogen atom, a C₁ -C₆ alkyl group, or a C₁ -C₆ alkenyl group), --L--OC(O)R¹² (wherein L is as defined above, and R¹² is a C₁ -C₆ alkyl group or a C₁ -C₆ alkoxy group), --L--S(O)_(n) R¹¹ (wherein L, n and R¹¹ are as defined above), --L--SC(O)R⁸ (wherein L and R⁸ are as defined above), ##STR42## (wherein each of L1 and L2 which may be the same or different is a methylene group, an oxygen atom or a sulfur atom, R¹² is a hydrogen atom or a C₁ -C₃ alkyl group, and m is 2 or 3); and a salt thereof.
 2. The pyrazole derivative of the formula I according to claim 1, wherein A, B, X, Y, Z and Q are as follows:A: Me, Et, n-Pr, i-Pr, CH₂ CH═CH₂, CH₂ C.tbd.CH, t-Bu B: H, Me, Et, n-Pr, i-Pr, Cl, Br, CH₂ Cl, CF₃, OMe, OEt, OPr-i, SMe, CH₂ OMe, CH₂ SMe, CO₂ Me, CO₂ Et X: Me, Et, n-Pr, i-Pr, n-Bu, i-Bu, S-Bu, t-Bu, OMe, OEt, OPr-n, OPr-i, OBu-n, OBu-i, OBu-s, OBu-t, F, Cl, Br, I, NO₂, CN, CH₂ F, CHF₂, CF₃, CH₂ CF₃, CHCl, CCl₃, CHClMe, CH₂ CH₂ Cl, CHClCH₂ Cl, CH₂ Br, CHBrMe, CH₂ CH₂ Br, CH₂ CH₂ Br, CH₂ OMe, CH₂ OEt, CH₂ OPr-n, CH₂ OPr-i, CH₂ OBu-n, CH₂ OBu-i, CH₂ OBu-s, CH₂ OBu-t, CHMeOMe, CHMeOEt, CHMeOPr-n, CHMeOPr-i, CHMeOBu-n, CHMeOBu-i, CHMeOBu-s, CHMeOBu-t, CH₂ CH₂ OMe, CH₂ CH₂ OEt, CH₂ CH₂ OPr-i, Ac, COEt, COPr-n, COPr-i, COOMe, COOEt, COOPr-i, CONHMe, CONHEt, CONMe₂, CONEt₂, CONEtMe, OCHF₂, OCF₃, OCH₂ CF₃, SMe, SEt, CH₂ SMe, CH₂ SEt, CHMeSMe, CHMeSEt Y: ##STR43## OCHMeCH═CH₂, OCMe₂ CH═CH₂, OCH₂ CMe═CH₂, OCH₂ CH═CHMe, OCH₂ CH═CMe₂, OCH₂ C.tbd.CH, OCHMeC.tbd.CH, OCMe₂ C.tbd.CH, OCH₂ C.tbd.CMe, OCH₂ CH₂ F, OCH₂ CHF₂, OCH₂ CF₃, OCH₂ CH₂ Cl, OCHMeCH₂ Cl, OCH₂ CCl₃, OCH₂ CH₂ CH₂ Cl, OCH₂ CH₂ Br, ##STR44## OCH₂ CCl═CH₂, OCH₂ CH₂ CH═CH₂, OCH₂ CCl═CHCl, OCH₂ CH₂ NO₂, OPh, OPh-Me-2 OPh-Cl-4, OPh-NO₂ -4, OCH₂ CH₂ OMe, OCH₂ CH₂ OEt, OCH₂ CH₂ OPr-n, OCH₂ CH₂ OPr-i, OCH₂ CH₂ OBu-N, OCH₂ CH₂ OBu-i, OCH₂ CH₂ Bu-s, OCH₂ CH₂ OBu-t, OCHMeCH₂ OMe, OCH₂ CH₂ OPh, OCH₂ CH₂ OCH₂ CH₂ OMe, OCH₂ CH₂ OH, OCH₂ CH₂ OCHMeCH₂ OMe, OCH₂ Ph, OCHMePh, OCH₂ Ph-4-Me, OCH₂ Ph-4-Cl, OCH₂ CH₂ Ph, ##STR45## OCH₂ CH₂ NH₂, OCH₂ CH₂ NHMe, OCH₂ CH₂ NMe₂, OCH₂ CH₂ NEt₂, ##STR46## OCH₂ COOMe, OCH₂ COOEt, OCH₂ COOPr-n, OCH₂ COOPr-i, OCH₂ COOBu-t, OCHMeCOOMe, OCHMeCOOEt OCHMeCOOPr-n, OCHMeCOOPr-i, OCHMeCOOBu-t, OCH₂ CH₂ CN, OCH₂ CN, OCHMeCN, OCH₂ SMe, OCH₂ C(O)Ph, OCH₂ C(O)Me, OCH₂ CH₂ SMe, OCH₂ CH₂ SOMe, OCH₂ CH₂ SO₂ Me, OCH₂ CH₂ SEt, OCH₂ CH₂ SO₂ Et, OCOOMe, OCOOEt, OCOOPr-i, OCONH₂, OCONHMe, OCONMe₂, OP(O)(OMe)₂, OP(O)(OEt)₂, ##STR47## SCH₂ CH═CH₂, SCH₂ C.tbd.CH, SCH₂ CF₃, SCH₂ CH₂ Cl, SCH₂ CCl₃, ##STR48## SPh,SCH₂ CH₂ OMe, SCH₂ CH₂ OEt, SCH₂ CH₂ OPr-i, SCH₂ CH₂ OPh, ##STR49## S(O)CH₂ CH═CH₂, S(O)CH₂ CH.tbd.CH, S(O)CH₂ CF₃, S(O)CH₂ CH₂ Cl, S(O)CH₂ ##STR50## S(O)Ph, S(O)CH₂ CH₂ OMe, S(O)CH₂ CH₂ OEt, S(O)CH₂ CH₂ OPr-i, S(O)CH₂ CH₂ OPh, ##STR51## SO₂ CH₂ CH═CH₂, SO₂ CH₂ C.tbd.CH, SO₂ CH₂ CF₃, SO₂ CH₂ CH₂ Cl, SO₂ CH₂ ##STR52## SO₂ Ph, SO₂ CH₂ CH₂ OMe, SO₂ CH₂ CH₂ OEt, SO₂ CH₂ CH₂ OPr-i, Z: F, Cl, Br, I, NO₂, OMe, OEt, OPr-n, OPr-I, CF₃, CN, SMe, SOMe, SO₂ Me, SCF₃, SOCF₃, SO₂ CF₃ Q H, Me, Et, n-Pr, i-Pr, n-Bu, i-Bu, s-Bu, t-Bu, CH₂ CH₂ Cl, CH₂ CF₃, CHClMe, CH₂ CH₂ Br, CHClCH₂ Cl, CH₂ CH═CH₂, CH₂ CMe═CH₂, CH₂ CH=CHMe, CH₂ C.tbd.CH, CH₂ CCl═CH₂, CH₂ CN, CH₂ Ph, CH₂ Ph-Cl-2, CH₂ Ph-Cl-3, CH₂ Ph-Me-2, ##STR53## CH₂ Ph-Me₂ -2,4, CH₂ Ph-Me-4, CHMePh, CHEtPh, CH₂ Ph-NO₂ -2, CH₂ Ph-CF₃ -3, CH₂ OMe, CH₂ OEt, CH₂ OH, CHMeOH, CH₂ NHMe, CH₂ NMe₂, CHMeNMe₂, CH₂ COPh, CH₂ COPh-NO₂ -4, CH₂ COPh-Me-4, CH₂ COPh-Cl-4, CH₂ COPh-Me-2,4, CH₂ COPh-CF₃ -4, CH₂ Ac, CH₂ COEt, CHMeAc, CH₂ CO₂ Me, CH₂ CO₂ Et, CH₂ CO₂ Pr-n, CH₂ COPr-i, CH₂ CO₂ Bu-t, CH₂ CO₂ H, CHMeCO₂ H, CH₂ CONHMe, CH₂ CONMe₂, CH₂ CONHEt, CH₂ CONEt₂, CH₂ CONPr-n₂, CH₂ OCH₂ CH═CH₂, CH₂ OAc, CH₂ COEt, CH₂ COPr-i, CH₂ COBu-t, CH₂ OCO₂ Me, CH₂ OCO₂ Et, CH₂ OCO₂ Pr-i, CH₂ OCO₂ Bu-t, CH₂ SMe, CH₂ SEt, CH₂ SCH₂ CH═CH₂, CH₂ SAc, CH₂ SCOBu-t, CH₂ SO₂ Me, CH₂ SO₂ Et, CH₂ SO₂ CH₂ CH═CH₂, COPh, COPh-Me-4, COPh-NO₂ -2, COPh-Cl₂ -2,4, Ac, COEt, COPr-n, COPr-i, COBu-n, COBu-t, CO₂ Me, CO₂ Et, CO₂ Bu-t, CO₂ Pr-i, CO₂ Ph, SO₂ Me, SO₂ Et, SO₂ Ph, SO₂ Ph-Me-4, SO₂ Ph-Cl-4, SO₂ Ph-(NO₂)₂ -2,4, P(═O)(OMe)₂, P(═O)(OEt)₂, P(═O)(OPr-n)₂, P(═O)(OPr-i)₂, P(═O)OMeOPh;and a salt thereof.
 3. A selective herbicidal composition comprising a herbicidally effective amount of a pyrazole derivative of the formula I as defined in claim 1 or its salt and an agricultural carrier or diluent.
 4. A method for controlling weeds, which comprise applying a herbicidally effective amount of a pyrazole derivative of the formula I as defined in claim 1 or its salt to a locus to be protected.
 5. A pyrazole derivative of the formula I ##STR54## wherein A is a C₁ -C₄ alkyl group, a C₂ -C₄ alkenyl group or a C₂ -C₄ alkynyl group;B is a hydrogen atom, a C₁ -C₃ alkyl group, a halogen atom, a C₁ -C₃ haloalkyl group, a C₁ -C₃ alkoxy group, a C₁ -C₃ alkylthio group, a C₂ -C₄ alkoxyalkyl group, a C₂ -C₄ alkylthioalkyl group or a C₂ -C₄ alkoxycarbonyl group; X is a C₁ -C₆ alkyl group, a C₁ -C₆ alkoxy group, a halogen atom, a nitro group, a cyano group, a C₁ -C₆ haloalkyl group, a C₂ -C₆ alkoxyalkyl group, a C₂ -C₆ alkylcarbonyl group, a C₂ -C₆ alkoxycarbonyl group, an aminocarbonyl group substituted independently by hydrogen or by a C₁ -C₆ alkyl group, a C₁ -C₆ haloalkoxy group, a C₁ -C₆ alkylthio group or a C₂ -C₆ alkylthioalkyl group; Y is --OR¹ (wherein R¹ is a C₃ -C₈ cycloalkyl group, a C₄ -C₈ cycloalkylalkyl group, a C₃ -C₆ alkenyl group, a C₂ -C₆ alkynyl group, a C₁ -C₆ haloalkyl group, a C₃ -C₈ halocycloalkylalkyl group, a C₃ -C₆ haloalkenyl group, a C₂ -C₆ haloalkynyl group, a C₂ -C₆ nitroalkyl group or a phenyl group which may be substituted by a C₁ -C₃ alkyl group, a halogen atom, a nitro group or a C₁ -C₃ alkoxy group), --O--L--O--R¹ (wherein L is a C₁ -C₆ alkylene group which may be substituted by a C₁ -C₃ alkyl group, and R¹ is as defined above), --O--L--OH (wherein L is as defined above), --O--L--O--L--O--R² (wherein L is as defined above, and R² is a hydrogen atom, a C₁ -C₆ alkyl group or a phenyl group which may be substituted by a C₁ -C₃ alkyl group, a halogen atom, a nitro group or a C₁ -C₃ alkoxy group), --O--L--R³ (wherein L is as defined above, and R³ is a phenyl group which may be substituted by a C₁ -C₃ alkyl group, a halogen atom, a nitro group or a C₁ -C₃ alkoxy group), --O--M (wherein M is a 3- to 6-membered alicyclic group containing not more than two sulfur or oxygen atoms and formed by a linkage of from 1 to 4 carbon atoms), --O--L--M (wherein L and M are as defined above), --O--L--NR⁴ R⁵ (wherein L is as defined above and each of R⁴ and R⁵ which may be the same or different is a hydrogen atom or a C₁ -C₆ alkyl group, or R⁴ and R⁵ form a 6-membered ring together with the adjacent nitrogen atom), --O--L--COOR⁴ (wherein L and R⁴ are as defined above), --O--CH═CH--COOR⁴ (wherein R⁴ is as defined above), --O--L--CN (wherein L is as defined above), --O--L--C(O)--R² (wherein L and R² are as defined above), --O--L--S(O)_(n) --R⁴ (wherein L and R⁴ are as defined above, and n is an integer of from 0 to 2), --O--COOR⁴ (wherein R⁴ is as defined above), --O--CONR⁴ R⁵ (wherein R⁴ and R⁵ are as defined above), --OP(O)(OR⁴)₂ (wherein R⁴ is as defined above), --S(O)_(n) R¹ (wherein R¹ and n are as defined above), or --S(O)_(n) --L--O--R¹ (wherein L, R¹ and n are as defined above); Z is a halogen atom, a nitro group, a C₁ -C₃ alkoxy group, a trifluoromethyl group, a trifluoromethoxy group, a cyano group or --S(O)_(n) R⁶ (wherein n is as defined above, and R⁶ is a C₁ -C₃ alkyl group or a C₁ -C₃ haloalkyl group); V is a hydrogen atom, a halogen atom, a C₁ -C₄ alkyl group or a C₁ -C₄ alkoxy group; W is a hydrogen atom, a halogen atom, a C₁ -C₄ alkyl group, a C₁ -C₄ haloalkyl group, a C₁ -C₄ alkoxy group, a C₂ -C₆ alkoxyalkyl group, a C₂ -C₅ alkoxycarbonyl group, a C₁ -C₃ haloalkoxy group, a nitro group, a cyano group or --S(O)_(n) --R⁶ (wherein n and R⁶ are as defined above); and Q is selected from the group consisting of CH₂ NHCH₂ CH═CH₂, CH₂ NMeCH₂ CH═CH₂, CH₂ NHAc, CH₂ NHCOEt, CH₂ NHCO₂ Me, CH₂ NHCO₂ Et, CH₂ NMeCO₂ Me, COCH₂ Cl, COCHCl₂, COCCl₃, COCF₃, COCH₂ OMe, COCH₂ OPh, COCH₂ CH═CHCH₃, CONHMe, CONMe₂, CONHEt, CONEt₂, CONPr-n₂, CON(CH₂ CH═CH₂)₂, CONMePh, ##STR55## CO₂ CH₂ Ph, SO₂ CH₂ CH═CH₂, SO₂ CF₃, P(═S)(OMe)₂, P(═S)(OEt)₂, P(═O)(OCH₂ CH═CH₂)₂, P(═O)OPhOCH₂ CH═CH₂ ; and salts thereof. 